Cradle

Company profile

About Cradle

Cradle is a protein engineering software platform that leverages artificial intelligence to accelerate the design and optimization of therapeutic and industrial proteins. The company serves leading biopharma and industrial biotechnology R&D teams, including Novo Nordisk, argenx, AbbVie, Johnson & Johnson, Novonesis, and Corteva. Cradle's platform enables scientists to generate protein candidates that meet multiple objectives simultaneously—including binding affinity, stability, expression, specificity, and activity—while learning from each round of experimental data. The technology works across diverse protein modalities including antibodies, enzymes, vaccines, and peptides, supporting programs from hit identification through lead optimization. Teams using Cradle report 2-12x faster development timelines compared to traditional protein engineering approaches. The platform integrates with existing experimental workflows, accepting data from NGS screening, FACS, chromatography, and various assay formats. Cradle's approach combines privacy-first AI with enterprise-grade security, ensuring customer data remains proprietary and is only used to train organization-specific models. The company operates its own wet lab in Amsterdam to continuously improve model performance and validate its AI algorithms with real-world experimental data. Founded to transform protein engineering from incremental progress to compounding results, Cradle enables scientists to explore multiple design strategies simultaneously, reducing the risk of project failure while strengthening IP portfolios. The platform is designed for teams developing therapeutics, agricultural solutions, food ingredients, and industrial biocatalysts.

Company description · Cradle official website