Unfold AI
AI-powered 3D prostate cancer mapping platform for precision treatment planning
Company profile
Company profile
Avenda Health is a precision medicine company focused on transforming prostate cancer care through artificial intelligence. The company's flagship product, Unfold AI, is an FDA-cleared platform that generates detailed 3D Cancer Estimation Maps (CEMs) to visualize the precise location and extent of prostate cancer within the prostate gland. By analyzing standard-of-care patient data including MRI scans, fusion biopsy results, pathology reports, and PSA levels, Unfold AI significantly outperforms traditional MRI in identifying where cancer resides. Clinical studies demonstrate that physicians using Unfold AI achieve 84% accuracy in identifying cancer extent, and patients treated with Unfold AI margins are 71% more likely to be cancer-free. The platform addresses a critical gap in prostate cancer treatment: without precise cancer mapping, whole-gland treatments lead to urinary and sexual dysfunction in over 50% of patients, while focal therapy without AI guidance leaves 24-49% of patients with residual cancer. Unfold AI supports multiple treatment modalities including active surveillance, prostatectomy, focal therapy, and radiotherapy by providing actionable insights for surgical planning, biopsy guidance, and treatment targeting. The technology is based on over 100,000 patient data points gathered over 10 years of research and validated in multiple peer-reviewed clinical studies. Avenda Health serves urologists, radiation oncologists, and healthcare systems across the United States, working to make precision-guided prostate cancer care accessible to patients nationwide.
Company description Avenda Health official website
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01 · Operating footprint
Company-profile context for clinical focus, customers, deployment, integration, milestones, and partnerships.
Cloud Saas deployment with recorded integration context.
Company milestones
CMS established national payment for Unfold AI (July 2024); Partnership with EDAP for world's first AI-assisted Focal One® Robotic HIFU procedures (September 2024); Won Top Digital Health Award at HLTH conference (October 2025); Multiple clinical study publications in 2024-2025
Partnerships
02 · Flagship portfolio
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AI-powered 3D prostate cancer mapping platform for precision treatment planning
03 · Research intelligence
Publications, preprints, clinical validation, and regulatory records in Evidence Position order.
Publications, clinical validation, and regulatory records connected to this Company appear here.
Research
The Journal of urology · Aug 1, 2025
Focal therapy of prostate cancer: Use of artificial intelligence to define tumour volume and predict treatment outcomes.BJUI compass · Jan 1, 2025
From Simulation to Surgery: Comprehensive Validation of an Optical Sensor for Monitoring Focal Laser Ablation of Solid Organ Tumors.IEEE sensors journal · Dec 15, 2024
Extracapsular extension risk assessment using an artificial intelligence prostate cancer mapping algorithm.BJUI compass · Oct 1, 2024
Artificial Intelligence Improves the Ability of Physicians to Identify Prostate Cancer Extent.The Journal of urology · Jul 1, 2024
Prediction and Mapping of Intraprostatic Tumor Extent with Artificial Intelligence.European urology open science · Aug 1, 2023
Clinical validation
NCT06047509 · Mentioned · TERMINATED
Regulatory
K221624 · 510k · Nov 22, 2022
04 · Company-reported outcomes
Company-reported outcomes and customer stories are distinct from linked Research Intelligence evidence.
Patients treated with Unfold AI margins versus conventional methods
Physicians' ability to identify prostate cancer extent using Unfold AI
Boost in cancer identification by urologists using the AI tool
Outperforms MRI in predicting prostate cancer spread and extracapsular extension
Deployed AI tool for enhanced prostate cancer identification
25% boost in cancer identification
Partnership to launch world's first AI-assisted Focal One® Robotic HIFU procedures
First-in-world AI-assisted robotic HIFU procedures for prostate cancer
Deployed AI cancer imaging technology to improve local access to cutting-edge prostate cancer care
Improved access to AI-assisted prostate cancer diagnosis and treatment planning
05 · Leadership
Leadership profiles and professional links from the current Company record.
Shyam Natarajan
Co-Founder & CEO
06 · Company updates
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No Company updates are currently listed.
07 · HAIC coverage
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08 · Official presence
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09 · Market pathway
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Market context
Companies using AI to analyze genomic, proteomic, metabolomic, or multi-omics data to provide personalized treatment recommendations, identify genetic risks, or develop targeted therapies. Includes genomic sequencing platforms with AI analysis, preventive medicine based on genetic risk assessment, and longevity care based on molecular and genetic data.
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