Health AI Central
Peer-Reviewed Publication
Am J Prev Cardiol2027;31101732.January 1, 2027Journal Article

Heart failure and atrial fibrillation prediction from non-gated chest CT scans using AI-based cardiac chamber volumetry: an AI-CVD study within the multi-ethnic study of atherosclerosis (MESA).

Seyed Reza Mirjalili1, Kyle Atlas1, Anthony P Reeves2, Chenyu Zhang1, Jakob Wasserthal3, Amir Azimi1, Ali Hashemi1, Mohammadhossein Mozafarybazargany1, Amir Ghaffari Jolfayi1, Thomas Atlas4, Claudia I Henschke5, David F Yankelevitz5, Javier J Zulueta5, Wenjun Fan6, Jeffrey I Mechanick7, Andrea D Branch5, Khurram Nasir8, Zahi Fayad9, Michael V McConnell10, Jamal S Rana11, Rozemarijn Vliegenthart12, David J Maron10, Jagat Narula13, Matthew J Budoff14, Roxana Mehran5, Kim A Williams15, Prediman K Shah16, Oren Mechanic17, Arthur S Agatston17, Robert A Kloner18, Nathan D Wong19, Morteza Naghavi1
1HeartLung.AI, Houston, TX, 77021, USA.
2Department of Electrical and Computer Engineering, Cornell University, Ithaca, NY. 14853, USA.
3Clinic of Radiology and Nuclear Medicine, University Hospital Basel, Petersgraben 4, CH-4031 Basel, Switzerland.
4Tustin Teleradiology, Tustin, CA 92780, USA.
5Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
6Department of Epidemiology and Biostatistics, Wen School of Public Health, University of California, Irvine, USA.
7Kravis Center for Clinical Cardiovascular Health, Mount Sinai Fuster Heart Hospital, New York, NY 10029 USA.
8Houston Methodist Hospital, Houston, TX 77030, USA.
9BioMedical Engineering and Imaging Institute. Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
10Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, CA, 94305, USA.
11Division of Cardiology, Kaiser Permanente Oakland Medical Center, California, USA.
12Department of Radiology, University Medical Center Groningen, GZ 9713, Netherlands.
13University of Houston, Houston, TX, 77030, USA.
14The Lundquist Institute, CA 90502, USA.
15University of Louisville, Louisville, KY, 40202, USA.
16Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
17The Agatston Center, Miami Beach, Florida, USA.
18Huntington Medical Research Institutes, Pasadena, CA, 91105, USA and Keck School of Medicine of University of Southern California, Los Angeles, CA 90033, USA.
19Heart Disease Prevention Program, Mary and Steve Wen Cardiovascular Division, University of California Irvine School of Medicine, CA 92697, USA.
PubMed PMC DOI PDF

Abstract

BACKGROUND: We previously demonstrated that AI-derived cardiac chamber volumetry in ECG-gated CT scans predicts atrial fibrillation (AF) and heart failure (HF). Since most chest CTs are non-gated, and the American Heart Association recently highlighted their value for opportunistic cardiovascular risk assessment using AI-based coronary artery calcium scoring, we extended this concept to evaluate w…

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