Peer-Reviewed Publication
Am J Prev Cardiol2027;31101712.January 1, 2027Journal Article
Whole heart atherosclerosis volume and risk for major adverse cardiovascular events across the clinical likelihood for obstructive CAD; the CONFIRM2 study.
Alexander van Rosendael1, Rine Nakanishi2, Jeroen J Bax3, Gianluca Pontone4,5, Saima Mushtaq6, Ronny R Buechel7, Christoph Gräni8, Gudrun Feuchtner9, Pietro G Lacaita9, Amit R Patel10, Cristiane C Singulane10, Andrew D Choi11, Mouaz Al-Mallah12, Daniele Andreini13, Ronald P Karlsberg14,15,16, Geoffrey Cho14,15,16, Carlos E Rochitte17, Mirvat Alasnag18, Ashraf Hamdan19, Filippo Cademartiri20, Erica Maffei21, Hugo Marques22, Pedro M Gonçalves Pereira22, Himanshu Gupta23, Martin Hadamitzky24, Omar Khalique25, Dinesh Kalra26, James D Mills27, Nick S Nurmohamed28,29, Paul Knaapen29, Matthew Budoff30, Kashif Shaikh31, Enrico Martin32, David M German33, Maros Ferencik33, Andrew C Oehler34, Roderick Deaño35, Prashant Nagpal36, Marly van Assen37, Carlo Nicola De Cecco37, Vasileios Kamperidis38, Borek Foldyna39, Jan Michael Brendel39, Victor Y Cheng40, Kelley Branch41, Marcio Bittencourt42, Sabha Bhatti43, Venkateshwar Polsani44, George Wesbey45, Rhanderson Cardoso46, Ron Blankstein46, Augustin Delago47,48, Amit Pursnani49,50, Amro Alsaid51, Vasvi Singh52, Melissa Aquino53, Ibrahim Danad54
1Department of Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands.
2Department of Cardiovascular Medicine, Toho University Graduate School of Medicine, Tokyo, Japan.
3Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.
4Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy.
5Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy.
6Perioperative Cardiology and Cardiovascular Imaging Department, Centro Cardiologico Monzino IRCCS, Milan, Italy.
7Department of Nuclear Medicine, Cardiac Imaging, University Hospital and University of Zurich, Zurich, Switzerland.
8Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
9Department of Radiology, Medical University of Innsbruck, Innsbruck, Austria.
10Division of Cardiovascular Medicine, University of Virginia, Charlottesville, VA, USA.
11Department of Cardiology and Radiology, George Washington University, Washington, District of Columbia, USA.
12Department of Cardiology, Houston Methodist, Houston, TX, USA.
13Division of University Cardiology, IRCCS Galeazzi Sant'Ambrogio, Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy.
14Cardiovascular Research Foundation of Southern California, Beverly Hills, CA, USA.
15Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
16David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
17Heart Institute, InCor, University of Sao Paulo Medical School, Sao Paulo, Brazil.
18Cardiac Center, King Fahad Armed Forces Hospital, Jeddah, Saudi Arabia.
19Department of Cardiology, Rabin Medical Center, Petah Tikva & Tel-Aviv University, Tel-Aviv, Israel.
20Istituto di Ricovero e Cura a Carattere Scientifico SYNLAB Servizi Diagnostici Nucleari, Naples, Italy.
21Department of Radiology, Istituto di Ricerca e Cura a Carattere Scientifico SYNLAB SDN, Naples, Italy.
22UNICA, Unit of Cardiovascular Imaging, Hospital da Luz, Imaging Department, Católica Medical School, Lisbon, Portugal.
23Cardiac Imaging, Heart and Vascular Institute, Valley Health System, Paramus, NJ, USA.
24Department of Cardiovascular Radiology and Nuclear Medicine, TUM University Hospital German Heart Center, Munich, Germany.
25Division of Cardiovascular Imaging, St. Francis Hospital and Heart Center, Roslyn, NY, USA.
26Division of Cardiology, Department of Medicine, University of Louisville School of Medicine, Louisville, KY, USA.
27Department of Medicine, Division of Cardiovascular Diseases & Hypertension, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ, USA.
28Department of Vascular Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
29Department of Cardiology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
30The Lundquist Institute, Torrance, CA, USA.
31University of Tennessee Medical Center, Knoxville, TN, USA.
32Division of Cardiology, MercyOne-Iowa Heart Center, Des Moines, IA, USA.
33Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, USA.
34Allegheny Health Network Cardiovascular Institute, Allegheny Health Network, Pittsburgh, PA, USA.
35Department of Medicine, Division of Cardiovascular Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
36Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
37Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA, USA.
381st Cardiology Department, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
39Department of Radiology, Cardiovascular Imaging and Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
40Minneapolis Heart Institute, Minneapolis, MN, USA.
41Division of Cardiology, University of Washington, Seattle, WA, USA.
42Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
43National Institute of Cardiovascular Diseases, Karachi, Pakistan.
44Piedmont Heart Institute, Atlanta, GA, USA.
45Department of Cardiovascular Computed Tomography, Scripps Clinic, La Jolla, CA, USA.
46Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, USA.
47Medical Data Research Collaborative, London, United Kingdom.
48Department of Medicine, Mount Auburn Hospital, Harvard Medical School, Cambridge, MA, USA.
49Cardiology, Endeavor NorthShore Cardiovascular Institute, Evanston, IL, USA.
50University of Chicago, Pritzker School of Medicine, Chicago, IL, USA.
51Department of Cardiac Imaging, Baylor Scott and White, The Heart Hospital Plano, Plano, TX, USA.
52Midwest Heart & Vascular Associates, Kansas City, MO, USA.
53Cleerly, Inc, Denver, CO, USA.
54Department of Cardiology, Radboud University Medical Center, Nijmegen, the Netherlands.
Abstract
INTRODUCTION: The totality of atherosclerosis from the coronary tree can be measured with quantitative coronary CT and is increasingly being recognized as important marker for future cardiovascular events. We evaluated the risk and absolute event rates of plaque volume staging systems and provided analyses according to the clinical likelihood of obstructive CAD.
METHODS: CONFIRM2 is an ongoing, g…
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