Health AI Central
Peer-Reviewed Publication
Eur Radiol2026October 15, 2026Journal Article

Low-dose vs standard-dose photon-counting CT for myopathy-associated interstitial lung disease: a prospective feasibility study.

Zhenchen Zhu1,2, Kepei Xu1,2, Yiyun Pang2,3, Ge Hu1,2,4, Luc Nicodème5, Johannes Hofmanninger5,6, Wei Han7, Sebastian Röhrich5, Georg Langs5,6, Jeanny Pan6, Mengzhe Lyu8, Xuemei Zhao9, Wei Guo10, Ying-Qian Ge8, Mengtao Li2,3, Zhengyu Jin1,2, Lan Song11,12, Shuang Zhou13,14, Qian Wang2,3,15
1Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
2State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Beijing, China.
3Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College; National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology; Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.
4Medical Research Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
5Department of Medical AI Solutions, Contextflow GmbH, Vienna, Austria.
6Computational Imaging Research Lab, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria.
7Department of Evidence-based Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China.
8Siemens Healthineers Digital Technology (Shanghai) Co. Ltd., Shanghai, China.
9Department of Radiology, The First People's Hospital of Yinchuan, The Second Affiliated Hospital of Ningxia Medical School, Yinchuan, China.
10Department of Radiology, The first Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, China.
11Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. songl@pumch.cn.
12State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Beijing, China. songl@pumch.cn.
13State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Beijing, China. doctorcat18@163.com.
14Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College; National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology; Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China. doctorcat18@163.com.
15State Key Laboratory of Common Mechanism Research for Major Diseases, Beijing, China.
PubMed DOI

Abstract

OBJECTIVES: To evaluate the clinical utility of photon counting computed tomography (PCCT)-derived quantitative parameters for assessing interstitial lung disease (ILD) burden in patients with inflammatory idiopathic myopathy (IIM), comparing standard-dose (SD) and tin-filtered low-dose (LD) protocols, and to assess the added value of ultrathin reconstructions. MATERIALS AND METHODS: In this sing…

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