Beyond detection: developing probabilistic hemodynamic phenotyping after a positive point-of-care pulmonary hypertension test.

Farhad Fathieh¹, Navid Nemati¹, Timothy Burton¹, Horace R Gillins², Ian Shadforth², Shyam Ramchandani¹, Charles R Bridges²

¹Analytics for Life, Toronto, ON, Canada.

²CorVista Health, Bethesda, MD, United States.

PubMed PMC DOI PDF

Abstract

BACKGROUND: Pulmonary hypertension (PH) is a heterogeneous condition in which hemodynamic subtype directs management and specialist referral. PH can be identified non-invasively at the point of care by a previously developed, regulatory-cleared machine-learned diagnostic (area under the receiver operating characteristic curve 0.95, sensitivity 82%, specificity 92%), but a positive test result rais…

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