Health AI Central
Peer-Reviewed Publication
J Appl Clin Med Phys2026;27(10):e70865.October 1, 2026Journal Article

Evaluation of online dose-guided adaptive fractionation for intact prostate radiotherapy.

Gevork S Gevorkyan1, Libing Zhu1, Riley C Tegtmeier2, Diego Santos Toesca1, Weiguo Lu3, Mingli Chen3, Yi Rong1, Quan Chen1
1Department of Radiation Oncology, Mayo Clinic Arizona, Phoenix, Arizona, USA.
2Department of Radiation Oncology, University of South Florida Morsani College of Medicine, Tampa, Florida, USA.
3Medical Artificial Intelligence and Automation Laboratory, UT Southwestern Medical Center, Dallas, Texas, USA.
PubMed DOI

Abstract

BACKGROUND: Dose-guided adaptive fractionation (DGAF) was proposed as a simpler alternative of adaptive radiation therapy, using organ variation simulation for proof of concept. However, its dosimetric benefit using actual daily anatomy changes in prostate cancer patients remains unclear. PURPOSE: The purpose of this study was to retrospectively evaluate the dosimetric benefit and potential risk…

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