Health AI Central
Peer-Reviewed Publication
JACC Adv2026;5(11 Pt 2):103321.September 22, 2026Journal Article

Validating ECG-Based Artificial Intelligence Models for Cardiomyopathy Detection in Obstetric Patients: A Multisite International Study.

Demilade Adedinsewo1, Patrick W Johnson2, Carolina Morales-Lara3, Maria Vitoria Coutinho4, Sabrina D Phillips4, Marc A Eidelhoch2, Michal Cohen-Shelly5, Elad Maor6, Ariel Furer7, Abraham Tsur8, Shali Mazaki-Tovi9, Kamilu M Karaye10, Bosede Bukola Afolabi11, Olusoji Edward Jagun12, Sadiq Hassan Ringim13, Kehinde Femi Ibiyemi14, Okechukwu Samuel Ogah15, Sabha Bhatti16, Shakeela Naz17, Haleema Yasmin18, Maedeh Ganji19, Jose Ruiz20, Khadeeja Esmail21, Jason Wheatley22, Anekwe Onwuanyi23, Eric Chang24, Myah M Griffin25, Oludamilola Oluleye26, Stefanie Gefroh27, Mohan Krishna Ranganathan28, Samir Awasthi28, Yvonne Butler Tobah29, Francisco Lopez-Jimenez30, Zachi I Attia30, Paul A Friedman30, Peter A Noseworthy30, Rickey E Carter2
1Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, Florida, USA. Electronic address: adedinsewo.demilade@mayo.edu.
2Department of Quantitative Health Sciences, Mayo Clinic, Jacksonville, Florida, USA.
3Department of Radiology, Emory University School of Medicine, Atlanta, Georgia, USA.
4Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, Florida, USA.
5Leviev Heart Center, Sheba Medical Center, Ramat Gan, Israel; ARC Innovation Center, Sagol AI Hub, Sheba Medical Center, Ramat Gan, Israel.
6Leviev Heart Center, Sheba Medical Center, Ramat Gan, Israel; ARC Innovation Center, Sagol AI Hub, Sheba Medical Center, Ramat Gan, Israel; Gray Faculty of Medical and Health Sciences, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel.
7Leviev Heart Center, Sheba Medical Center, Ramat Gan, Israel; Department of Military Medicine, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
8Department of Obstetrics and Gynecology, The Sheba Medical Center, Tel Hashomer, Israel; The Dina Recanati School of Medicine, Reichman University, Herzliya, Israel.
9ARC Innovation Center, Sagol AI Hub, Sheba Medical Center, Ramat Gan, Israel; Department of Obstetrics and Gynecology, The Sheba Medical Center, Tel Hashomer, Israel.
10Department of Medicine, Aminu Kanu Teaching Hospital and Bayero University, Kano, Nigeria.
11Department of Obstetrics and Gynecology, College of Medicine, University of Lagos, Idi-Araba, Lagos, Nigeria; Centre for Clinical Trials, Research and Implementation Science, University of Lagos College of Medicine, Idi-Araba, Lagos, Nigeria.
12Department of Obstetrics and Gynecology, Olabisi Onabanjo University Teaching Hospital, Sagamu, Ogun, Nigeria.
13Department of Medicine, Rasheed Shekoni Federal University Teaching Hospital, Dutse, Jigawa, Nigeria.
14Department of Obstetrics and Gynecology, University of Ilorin Teaching Hospital, Ilorin, Nigeria.
15Cardiology Unit, Department of Medicine, University of Ibadan, Ibadan, Oyo, Nigeria.
16Department of Adult Cardiology, National Institute of Cardiovascular Diseases (NICVD), Karachi, Pakistan; Department of Cardiology, Rutgers Robert Wood Johnson University Hospital, New Brunswick, New Jersey, USA.
17Department of Adult Cardiology, National Institute of Cardiovascular Diseases (NICVD), Karachi, Pakistan.
18Department of Obstetrics and Gynecology, Jinnah Postgraduate Medical Centre (JPMC), Jinnah Sindh Medical University, Karachi, Pakistan.
19Baptist Beaches Cardiology Center, Baptist Health, Jacksonville, Florida, USA.
20Department of Transplant, Mayo Clinic, Jacksonville, Florida, USA.
21Department of Cardiology, University of Florida College of Medicine, Jacksonville, Florida, USA.
22Department of Obstetrics and Gynecology, University of Florida College of Medicine, Jacksonville, Florida, USA.
23Department of Cardiology, Morehouse School of Medicine, Atlanta, Georgia, USA.
24Department of Cardiology, West Georgia Cardiology, Carrollton, Georgia, USA.
25Department of Obstetrics and Gynecology, Morehouse School of Medicine, Atlanta, Georgia, USA; Center for Maternal Health Equity, Department of Community Health and Preventive Medicine, Morehouse School of Medicine, Atlanta, Georgia, USA.
26Department of Cardiology, Essentia Health Heart and Vascular Center, Fargo, North Dakota, USA.
27Department of Obstetrics and Gynecology, Essentia Health, Fargo, North Dakota, USA.
28Anumana Inc, Cambridge, Massachusetts, USA; Nference Inc, Cambridge, Massachusetts, USA.
29Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, Minnesota, USA.
30Department of Cardiology, Mayo Clinic, Rochester, Minnesota, USA.
PubMed DOI

Abstract

BACKGROUND: Cardiomyopathy significantly impacts maternal health worldwide. Artificial intelligence-enabled electrocardiograms (AI-ECG) have shown effectiveness in detecting left ventricular systolic dysfunction (LVSD) in adults and limited obstetric cohorts; however, broad validation in diverse obstetric populations remains unexplored. OBJECTIVES: Our primary objective was to validate the perfor…

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