Health AI Central
Peer-Reviewed Publication
EULAR Rheumatol Open2026;2(3):100203.September 1, 2026Journal Article

From pixels to prediction: improving imaging through AI in rheumatology.

Peter Mandl1,2, Xenofon Baraliakos3, Vincent Bouget4, Peter Böhm5, Martin Brom6, Michael Deman7, Thomas Hügle8, Arnd Kleyer9, Georg Langs10,11, Anastasiia Miendrova12, Isabel Morales Ivorra13, Joeri Nicolaes14,15, Anders Nordell16, Mikkel Østergaard17,18, Costantino Pitzalis19,20, Karin Rainer21, Kristian Reich22,23, Thiusius Rajeeth Savarimuthu24,25, Daniela Sieghart1, Clemens Watzenböck10,11, Loreto Carmona26, Robert Janiczek27, Daniel Aletaha1
1Division of Rheumatology, Medical University of Vienna, Vienna, Austria.
2Ludwig Boltzmann Institute of Arthritis and Rehabilitation, Vienna, Austria.
3Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Herne, Germany.
4Scienta Lab, Paris, France.
5Patient Research Partner, EULAR, Kilchberg, Switzerland.
6Translational Medicine, Novartis Biomedical Research, Novartis Campus, Basel, Switzerland.
7Janssen Pharmaceutica NV, a Johnson & Johnson Company, Beerse, Belgium.
8Department of Rheumatology, University Hospital Lausanne (CHUV) and University of Lausanne, Lausanne, Switzerland.
9Department of Rheumatology and Clinical Immunology, Charité-Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany.
10Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria.
11Comprehensive Center for Artificial Intelligence in Medicine, Medical University of Vienna, Vienna, Austria.
12European Alliance of Associations for Rheumatology (EULAR), Kilchberg, Switzerland.
13Singularity Biomed, Sant Cugat del Vallès, Spain.
14UCB Pharma, Brussels, Belgium.
15Department of Electrical Engineering (ESAT), Center for Processing Speech and Images, KU Leuven, Leuven, Belgium.
16Collective Minds Radiology, Danderyd, Sweden.
17Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Denmark.
18Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
19Centre for Experimental Medicine & Rheumatology, William Harvey Research Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK.
20Barts Health NHS Trust and National Institute for Health and Care Research (NIHR) Barts Biomedical Research Centre (BRC), Charterhouse Square, London, London, UK.
21Austrian Agency for Health and Food Safety GmbH, Vienna, Austria.
22MoonLake Immunotherapeutics AG, Zug, Switzerland.
23Translational Research in Inflammatory Skin Diseases, Institute for Health Services Research in Dermatology and Nursing, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
24ROPCA ApS, Odense, Denmark.
25University of Southern Denmark, Odense, Denmark.
26Instituto de Salud Musculoesquelética, Madrid, Spain.
27Johnson & Johnson, Spring House, PA, USA.
PubMed PMC DOI PDF

Abstract

Imaging plays a central role in the diagnosis, monitoring, and prediction of rheumatic and musculoskeletal diseases (RMDs), yet its clinical and regulatory impact remains limited by variability, the lack of standardisation and metrics for quantification, and slow clinical translation. Artificial intelligence (AI) offers unique opportunities to overcome these barriers through automated segmentation…

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