SCAPIS 2 spectrum: rationale, objectives and design of a microvascular dysfunction sub-study within the Swedish CArdioPulmonary bioImage study.

Jacob Widaeus^1,2, Kerstin Welén Schef^1,3, Tomas Jernberg^1,3, Mattias Windå⁴, Fredrik Salomonsson⁴, Henrik Johansson⁴, Jannike Nickander^5,6, Helge Brandberg^1,3, Maria Cronhjort^1,7, Sara Tehrani^1,2

¹Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden.

²Department of Medical Specialties, Danderyd Hospital, Stockholm, Sweden.

³Department of Cardiology, Danderyd Hospital, Stockholm, Sweden.

⁴Neko Health AB, Stockholm, Sweden.

⁵Department of Clinical Physiology, Karolinska University Hospital, Stockholm, Sweden.

⁶Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.

⁷Department of Anaesthesia and Intensive Care, Danderyd Hospital, Stockholm, Sweden.

PubMed PMC DOI PDF

Abstract

UNLABELLED: The microvasculature forms the interface for nutrient exchange and signaling between the blood and tissues. Its dysfunction is increasingly recognized as a key mechanism underlying various cardiovascular diseases, including heart failure, ischemic heart disease, atherosclerosis, stroke and vascular dementia. Early detection of these subclinical processes using non-invasive assessments…

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