Health AI Central
Peer-Reviewed Publication
Clin Cancer Res2026October 8, 2026Journal Article

Multi-institutional Patient-level Comparison of Decipher Genomic Classifier and Artera Multimodal Artificial Intelligence (MMAI) in Prostate Cancer.

Boon Hao Hong1, Adeniyi A Olabumuyi2, Shuang G Zhao3, Purvish Trivedi4, Ryan Putney5, Esther Katende5, Amparo Serna6, Riley Smith7, Jasreman Dhillon8, Jong Y Park6, Rodrigo Pessoa4, Michael Poch6, Daniel Grass7, Julio Pow-Sang6, Alexander Hakansson9, Yang Liu10, Elai Davicioni11, Yi Ren12, Siyi Tang12, Danielle Croucher12, Huei-Chung Huang12, S Laura Chang12, Mary Feng13, Rikiya Yamashita12, Enya H W Ong1, Kae Jack Tay14, Kah Min Tan1, Jeffrey K L Tuan1, Michael L C Wang1, Li Yan Khor14, Olivia G Jordan15, Jinhee Chang16, Claudia Datnow-Martinez15, Xiaolei Shi15, Amol Shetty17, Zaker H Rana15, Jason K Molitoris17, Mark V Mishra15, Young Kwok18, Yang Song17, Matthew Ramotar19, Alejandro Berlin20, Ozan Guler21, Cem Onal22, Loig Vaugier23, Audrey Blanc-Lapierre24, Stéphane Supiot25, Carole Mercier26, Piet Dirix26, Piet Ost27, Ryan J Park28, Chad Tang29, Michael K Rooney28, Shalin Shah28, Lauren Mayo28, Seungtaek Choi28, Steven J Frank28, Comron Hassanzadeh28, Karen Hoffman30, Sean McGuire28, Osama Mohamad28, Henry Mok28, Quynh-Nhu Nguyen31, Krishnan R Patel28, Theodore DeWeese32, Ana P Kiess33, Daniel Song34, Scott E Delacroix35, Daniel E Spratt36, Paul L Nguyen37, Matthew Deek38, Phuoc T Tran39, Philip Sutera40, Melvin L K Chua1, Kosj Yamoah6
1National Cancer Centre Singapore Singapore Singapore.
2University of Maryland Medical Center Baltimore, MD United States.
3University of Wisconsin-Madison Madison, Wisconsin United States.
4Moffitt Cancer Center Tampa United States.
5H. Lee Moffitt Cancer Center & Research Institute Tampa, FL United States.
6Moffitt Cancer Center Tampa, FL United States.
7Moffitt Cancer Center Tampa, Florida United States.
8H. Lee Moffitt Cancer center and research Institute Tampa, FL United States.
9Veracyte San Diego United States.
10Veracyte (United States) United States.
11Veracyte (United States) San Diego, California United States.
12Artera Los Altos, California United States.
13University of California, San Francisco San Francisco, CA United States.
14Singapore General Hospital Singapore.
15University of Maryland Medical Center United States.
16Michigan State University East Lansing, MI United States.
17University of Maryland, Baltimore United States.
18University of Maryland School of Medicine Baltimore, MD United States.
19Princess Margaret Cancer Centre Toronto, Ontario, Canada.
20University of Toronto Canada.
21Rutgers, The State University of New Jersey Adana Turkey.
22Baskent University Turkey.
23Institut de Cancérologie de l'Ouest Saint Herblain France.
24Institut de Cancérologie de l'Ouest Saint-Herblain France.
25Centre de Recherche en Cancérologie Immunologie de Nantes Angers Nantes cedex 1 France.
26Iridium Kankernetwerk Belgium.
27Ghent University Gent Belgium.
28The University of Texas MD Anderson Cancer Center Houston, TX United States.
29The University of Texas MD Anderson Cancer Center Houston, tx United States.
30The University of Texas MD Anderson Cancer Center United States.
31The University of Texas MD Anderson Cancer Center Houston United States.
32Johns Hopkins Medicine Baltimore, MD United States.
33Johns Hopkins University Baltimore, Maryland United States.
34Johns Hopkins Hospital Baltimore, Maryland United States.
35Mary Bird Perkins Cancer Center Metairie, Louisiana United States.
36University Hospitals Cleveland Medical Center Cleveland, OH United States.
37Brigham and Women's Hospital Boston, MA United States.
38Rutgers, The State University of New Jersey New Brunswick, New Jersey United States.
39University of Maryland, College Park Baltimore, MD United States.
40University of Rochester Medical Center Rochester, New York United States.
PubMed DOI

Abstract

IMPORTANCE: The Decipher Prostate Genomic Classifier (GC) and ArteraAI Multimodal Artificial Intelligence (MMAI) platform are widely used prognostic tools for localized prostate cancer (PCa), yet no direct comparison has been performed within the same patient cohort. METHODS: We sought to evaluate the concordance and prognostic value of GC and MMAI across multi-institutional cohorts totaling 688…

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