Health AI Central
Peer-Reviewed Publication
Ann Oncol2026October 7, 2026Letter

Postoperative ctDNA dynamics and eligibility for Treat-on-Molecular Result (TOMR) ALTAIR trial in colorectal cancer: insights from CIRCULATE-Japan.

Y Nakamura1, H Bando2, V N Aushev3, J Watanabe4, Y Takahashi5, M Kotaka6, N Matsuhashi7, E Oki8, Y Komatsu9, M Shiozawa10, K Hirata11, Y Miyamoto12, M Takahashi13, K Yamazaki14, D Manaka15, A Kanazawa16, Y-H Liang17, K-H Yeh17, C C Palsuledesai3, R W Lentz3, A Jurdi3, M C Liu3, M Rabinowitz3, S Mishima18, I Takemasa19, D Kotani18, A Sato20, T Misumi21, H Taniguchi22, T Yoshino23, T Kato5
1Translational Research Support Office, National Cancer Center Hospital East, Kashiwa, Japan; Department of Oncology, University of Oxford, Oxford, UK.
2Translational Research Support Office, National Cancer Center Hospital East, Kashiwa, Japan; Department of Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan.
3Natera, Inc., Austin, TX, USA.
4Department of Colorectal Surgery, Kansai Medical University, Hirakata, Japan; Department of Surgery, Gastroenterological Center, Yokohama City University Medical Center, Yokohama, Japan.
5Department of Surgery, NHO Osaka National Hospital, Osaka, Japan.
6Gastrointestinal Cancer Center, Sano Hospital, Kobe, Japan.
7Department of Gastroenterological Surgery and Pediatric Surgery, Gifu University Graduate School of Medicine, Gifu, Japan.
8Department of Advanced Medicine and Innovative Technology, Kyushu University, Fukuoka, Japan.
9Department of Cancer Center, Hokkaido University Hospital, Sapporo, Japan.
10Department of Gastroenterological Surgery, Kanagawa Cancer Center, Yokohama, Japan.
11Department of Surgery 1, University of Occupational and Environmental Health, Kitakyushu, Japan.
12Department of Gastroenterological Surgery, Kumamoto University, Kumamoto, Japan.
13Department of Medical Oncology, Tohoku University Hospital, Sendai, Japan.
14Division of Gastrointestinal Oncology, Shizuoka Cancer Center, Shizuoka, Japan.
15Department of Surgery, Kyoto Katsura Hospital, Kyoto, Japan.
16Department of Surgery, Shimane Prefectural Central Hospital, Shimane, Japan.
17Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan.
18Department of Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan.
19Department of Surgery, Osaka International Medical & Science Center, Osaka, Japan.
20Clinical Research Support Office, National Cancer Center Hospital East, Kashiwa, Japan.
21Department of Data Science, National Cancer Center Hospital East, Kashiwa, Japan.
22Department of Clinical Oncology, Aichi Cancer Center, Nagoya, Japan.
23Department of Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan. Electronic address: tyoshino@east.ncc.go.jp.
PubMed DOI

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