Peer-Reviewed Publication
Oncologist2026October 1, 2026Journal Article

Precision Oncology at Speed: Workflow Design Determines Clinical Utility in Rapid Molecular Testing for Lung Cancer.

Brandon S Sheffield1,2, Katherina Baranova2,3, Parneet Cheema2, Miriam A Bredella4, Champica Nicholas1,2, Ibiayi Dagogo-Jack5, Jochen K Lennerz6
1Division of Advanced Diagnostics, William Osler Health System, Brampton, Canada.
2Osler Research Institute for Health Innovation, Brampton, Canada.
3London Health Sciences Centre (LHSC), London, Ontario, Canada.
4NYU Langone Health, Grossman School of Medicine, New York, NY, USA.
5Massachusetts General Hospital, Cancer Center, Boston, MA, USA.
6Natera, Austin, TX, USA.

Abstract

PURPOSE: Matching patients with effective targeted therapies requires timely molecular results, however the challenge today how to embed it into routine clinical workflows in ways that meaningfully affect patient-level treatment decisions. METHODS: Building on prior work, the authors systematically reviewed laboratory operations, interdepartmental coordination, and administrative processes from t…

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