Health AI Central
Peer-Reviewed Publication
Res Sq2026September 11, 2026Journal Article

CYLD Mutations, PD-L1 and HPV; A Pan-Cancer Landscape Analysis.

Umut Dişel1, Saumya Dushyant Sisoudiya2, Smruthy Sivakumar2, Razelle Kurzrock3
1Acıbadem Adana Hospital.
2Foundation Medicine Inc.
3Medical College of Wisconsin Cancer Center.
PubMed PMC DOI PDF

Abstract

BACKGROUND: CYLD, a tumor suppressor gene encoding a deubiquitinase enzyme, regulates tumorigenesis via NF-κB signaling. CYLD mutations are linked to immune evasion and PD-L1 upregulation, particularly in virus-associated cancers. We evaluated CYLD alterations across cancers and their correlation with PD-L1 expression. Given the established link between CYLD dysfunction and viral oncogenesis, we a…

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