Health AI Central
Peer-Reviewed Publication
AAPS PharmSciTech2026;27(7)September 29, 2026Journal Article

Navigating Surfactant Selection in In Vitro Dissolution Testing: Mechanistic Insights and Practical Strategies.

Sushesh Srivatsa Palakurthi1,2, Niloufar Salehi3, Jie Shen4, Sanjaykumar Patel5, Nikoletta Fotaki6, Deanna Mudie7, Sumedha Kapre1, Pradnya Bapat3, Christopher Rego8, David B Turner9, Omid Arjmandi-Tash10, Zizhao Xu11, Shriram M Pathak12, Karina I Vazquez3, Vivian Gray13
1Department of Pharmaceutical Sciences, Texas A&M Irma Lerma Rangel College of Pharmacy, Kingsville, Texas, 78363, USA.
2Formulation R&D, ARx Pharmaceuticals LLC, Borough, Pennsylvania, 17327, USA.
3Eli Lilly & Company, Indianapolis, Indiana, 46285, USA.
4Department of Pharmaceutical and Biomedical Sciences, Northeastern University, Boston, Massachusetts, 02115, USA. jie.shen@northeastern.edu.
5Merck & Co., Inc.,, Rahway, New Jersey, 07065, USA. sanjaykumar.patel@merck.com.
6Department of Life Sciences, University of Bath, Bath, BA2 7AY, UK.
7Simulations Plus, Research Triangle Park, Durham County, North Carolina, 27709, USA.
8Analytical Development Synthetic Molecules, Takeda Development Center Americas, Inc., Cambridge, Massachusetts, 02142, USA.
9Certara, Simcyp Division, Sheffield, S1 2BJ, UK.
10Pfizer, Sandwich, Kent, CT13 9NJ, UK.
11Department of Pharmaceutical and Biomedical Sciences, Northeastern University, Boston, Massachusetts, 02115, USA.
12Eisai Ltd., Hatfield, AL10 9SN, UK.
13V.A. Gray Consulting, Inc.,, Hockessin, Delaware, 19707, USA.
PubMed DOI

Abstract

In vitro dissolution testing is central to pharmaceutical development, yet it is increasingly challenged by poorly soluble drugs, which account for over 40% of marketed products and up to 90% of new chemical entities, for which dissolution often limits absorption. Surfactants are widely incorporated into dissolution media to achieve sink conditions and improve the discriminatory powder of dissolut…

Create a free account to keep reading

Free members get 10 full research views every month across publications, clinical trials, FDA clearances, adverse events, and NIH grants. No credit card required.

Create Free AccountSign In

Want unlimited research access? See Pro plans

Data Accuracy Notice: Research intelligence on Health AI Central is aggregated from public sources (PubMed, ClinicalTrials.gov, FDA, NIH, CMS, and others) and refreshed nightly. Classifications and derived metrics are produced by automated methods described in our Methodology. We recommend verifying critical data points against the primary sources before making decisions.