Microstructural changes in deep gray nuclei following electroconvulsive therapy.

Christopher G Filippi¹, Matthew Yh Leung², Aziz M Ulug², Artemis Zavaliangos-Petropulu², Richard Watts²

¹From the Radiology (C.G.F.), Neuroscience and Mental Health (C.G.F.), The Hospital for Sick Children, Toronto, Canada; Neuroradiology (M.Y.H.L.), Department of Medical Imaging, University of Toronto, Toronto, Canada; School of Medicine (M.Y.H.L.), The University of Sydney, Sydney, Australia; Cortechs Labs (A.M.U.), San Diego, USA; Biyomedikal Mühendisliği Enstitüsü (A.M.U.), Boğaziçi University, Istanbul, Turkey; Ahmanson-Lovelace Brain Mapping Center, Department of Neurology (A.Z.-P.), Geffen School of Medicine at the University of California, Los Angeles, CA, USA and University of Canterbury (R.W.), Christchurch, New Zealand. risto.filippi@sickkids.ca.

²From the Radiology (C.G.F.), Neuroscience and Mental Health (C.G.F.), The Hospital for Sick Children, Toronto, Canada; Neuroradiology (M.Y.H.L.), Department of Medical Imaging, University of Toronto, Toronto, Canada; School of Medicine (M.Y.H.L.), The University of Sydney, Sydney, Australia; Cortechs Labs (A.M.U.), San Diego, USA; Biyomedikal Mühendisliği Enstitüsü (A.M.U.), Boğaziçi University, Istanbul, Turkey; Ahmanson-Lovelace Brain Mapping Center, Department of Neurology (A.Z.-P.), Geffen School of Medicine at the University of California, Los Angeles, CA, USA and University of Canterbury (R.W.), Christchurch, New Zealand.

PubMed DOI

Abstract

BACKGROUND AND PURPOSE: Electroconvulsive therapy (ECT) is efficacious for the treatment of major depressive disorder. However, its underlying mechanism of action remains debated and may involve neurogenesis, changes in axon/synaptic density or glial cells. Restriction spectrum imaging (RSI) is an MRI technique that can resolve subvoxel microstructure, separating intracellular water from extracell…

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