Detection of Chagas Disease from the ECG: The George B. Moody PhysioNet Challenge 2025.

Matthew A Reyna¹, Soheil Saghafi¹, Zuzana Koscova¹, Audrey Weigle¹, Jan Pavlus¹, Andoni Elola², Salman Seyedi¹, Kiersten Campbell¹, Qiao Li¹, Sandhi Barreto³, Ester Cerdeiro Sabino⁴, Antonio Horta Ribeiro⁵, Antonio Luiz Pinho Ribeiro⁶, Reza Sameni¹, Gari D Clifford¹

¹Department of Biomedical Informatics, Emory University, 101 Woodruff Circle, Atlanta, Georgia, 30322, United States.

²Department of Electronic Technology, University of the Basque Country Bilbao School of Engineering, Plaza Ingeniero Torres Quevedo, Bilbao, PV, 48013, Spain.

³Department of Preventive and Social Medicine, Universidade Federal de Minas Gerais, Av. Prof. Alfredo Balena, 190, Belo Horizonte, Minas Gerais, 30130-100, Brazil.

⁴Department of Infectious Diseases, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Av. Dr. Enéas Carvalho de Aguiar, 470, São Paulo, São Paulo, 05403-010, Brazil.

⁵Department of Information Technology, Uppsala Universitet, hus 10, Regementsvägen 10, Uppsala, 751 05, Sweden.

⁶Department of Internal Medicine, Universidade Federal de Minas Gerais, Av. Prof. Alfredo Balena, 110 - Santa Efigênia, Belo Horizonte, Minas Gerais, 31270-901, Brazil.

PubMed DOI

Abstract

Chagas disease is a parasitic infection that is endemic to Latin America and primarily transmitted by insects. When untreated, Chagas disease can cause cardiomyopathy. Serological testing capacities for Chagas disease are limited, but Chagas cardiomyopathy often manifests in electrocardiograms (ECGs), providing an opportunity to use ECG-based screening to prioritize patients for testing and treatm…

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