Health AI Central
Peer-Reviewed Publication
Neuro Oncol2026September 26, 2026Journal Article

Association of high tumor mutational burden with brain metastases: Insights from a large-scale database analysis.

Marana Abboud1,2, Saumya Sisoudiya3, Benjamin Kaplan3, Tomer Elisha1,2, Laureen Goodman1,2, Fayhaa Khair1,2, Smruthy Sivakumar3, Ethan Sokol3, Ido Wolf1,2, Tami Rubinek1,2
1The Oncology Division, Tel Aviv Sourasky Medical Center, Israel.
2Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.
3Foundation Medicine Inc., Boston, Massachusetts, USA.
PubMed DOI

Abstract

BACKGROUND: Brain metastases (BrM) are a major cause of cancer-related mortality. To successfully colonize the brain, cancer cells must acquire unique adaptations. We hypothesized that BrM, regardless of their primary tumor origin, share convergent molecular features enabling brain colonization while retaining tumor type-specific alterations. METHODS: We analyzed genomic data from 150,486 tumor s…

Create a free account to keep reading

Free members get 10 full research views every month across publications, clinical trials, FDA clearances, adverse events, and NIH grants. No credit card required.

Create Free AccountSign In

Want unlimited research access? See Pro plans

Data Accuracy Notice: Research intelligence on Health AI Central is aggregated from public sources (PubMed, ClinicalTrials.gov, FDA, NIH, CMS, and others) and refreshed nightly. Classifications and derived metrics are produced by automated methods described in our Methodology. We recommend verifying critical data points against the primary sources before making decisions.