Peer-Reviewed Publication
Eur J Prev Cardiol2026September 18, 2026Journal Article
Gene-environment interactions shape cytokine-mediated inflammation and cardiovascular risk.
Mattia Corianò1,2, Shamin Tahasildar1, Ling Huang1,3, Khaled Rjoob1, Majid Vafaeezadeh1, Soodeh Kalaie1,3, Jin Zheng1, Lara Curran1,4,5, Parisa Gifani1, Marc-Emmanuel Dumas6,7,8, Declan P O'Regan1
1MRC Laboratory of Medical Sciences, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0HS, UK.
2Department of Cardiac, Thoracic, Vascular Science and Public Health, University of Padova, Padova, Italy.
3Department of Computing, Imperial College London, London, UK.
4National Heart and Lung Institute, Imperial College London, London, UK.
5Royal Brompton and Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK.
6Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
7Multi-omics and Pathophysiology of Metabolic Disease Unit, Lille University Hospital, Lille, France.
8Antoine Lavoisier Multiscale Metabolism International Research Laboratory, Imperial College London, London, UK.
Abstract
BACKGROUND: Chronic inflammation is a major driver of cardiovascular diseases, but mechanisms linking systemic inflammation to cardiac remodelling remain incompletely understood. We aimed to evaluate the role of cytokine-mediated signalling and the influence of environmental and genetic factors on inflammation and cardiac phenotypes in a large population-based cohort.
METHODS: We analysed subsets…
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