Natural language processing-based model to predict radiation pneumonitis in patients with locally advanced non-small cell lung cancer undergoing chemoradiotherapy: a retrospective cohort study.

Julie R Bloom¹, Nicole Tignor², Tielman Van Vleck², Dexter P Mendoza³, Sooyun Caroline Tavolacci^4,5, Olivia Fankuchen⁶, Glen Chun⁷, Stephanie Chang⁴, Michael Chung⁸, Stephanie Tuminello^9,10, Fred R Hirsch⁴, Abraham Chachoua⁶, Joshua K Sabari⁶, Juan Wisnivesky^7,11, Ion Cotarla¹², Daniel Simmons¹³, Kristin Hsieh^1,13, Chris Tackaberry¹⁴, Kenneth E Rosenzweig¹, Robert M Samstein¹, Pei Wang², Rajwanth R Veluswamy⁶

¹Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

²Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, 1428 Madison Ave., New York, NY, USA.

³Department of Radiology, NYU Langone Health, New York, NY, USA.

⁴Center for Thoracic Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

⁵Department of Radiation Medicine, Westchester Medical Center, Valhalla, NY, USA.

⁶Department of Hematology and Oncology, NYU Langone Health Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, NY, USA.

⁷Division of Pulmonary Medicine, Critical Care and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

⁸Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

⁹Institute for Translational Epidemiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

¹⁰Department of Thoracic Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

¹¹Division of General Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

¹²AstraZeneca, US Medical Affairs, Gaithersburg, MD, USA.

¹³AstraZeneca, Oncology Outcomes Research, Gaithersburg, MD, USA.

¹⁴Clinithink, New Kings Beam House, London, London, UK.

PubMed PMC DOI PDF

Abstract

BACKGROUND: Radiation pneumonitis (RP) remains a significant treatment-related toxicity in patients with unresectable, locally advanced non-small cell lung cancer (NSCLC) undergoing chemoradiotherapy (CRT). Most existing predictive models rely on static baseline demographic or dosimetry variables and lack real-time clinical applicability. We developed a novel predictive framework that integrates l…

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