Nucleic Acid Turnover and Lipid Remodeling Distinguish T Cell Activation and Exhaustion States via Label-Free Raman Spectroscopy.

Marissa Morales¹, Srilakshmi Premachandran², Shruthi Ravichandran^3,4, Loza F Tadesse^2,5,6

¹Department of Health Sciences & Technology, MIT, Cambridge, Massachusetts02139, United States.

²Department of Mechanical Engineering, MIT, Cambridge, Massachusetts02139, United States.

³Department of Electrical Engineering & Computer Science, MIT, Cambridge, Massachusetts02139, United States.

⁴Department of Architecture, MIT, Cambridge, Massachusetts02139, United States.

⁵Ragon Institute of Massachusetts General Hospital, MIT & Harvard, Cambridge, Massachusetts02139, United States.

⁶Jameel Clinic for AI & Healthcare, MIT, Cambridge, Massachusetts02139, United States.

PubMed DOI

Abstract

T cell exhaustion has widespread implications for the progression and treatment of chronic diseases including tuberculosis, HIV, malaria, and cancer, yet current detection methods require expensive and tedious antibody labeling, destructive workflows, or days-long functional assays that limit dynamic monitoring capabilities. Here, we introduce Raman spectroscopy as a label-free assay for distingui…

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