Sex differences in human deep grey matter microstructure emerge during adolescence.

Christopher G Filippi¹, Jay N Giedd², Aziz M Uluğ³, Richard Watts⁴

¹The Hospital for Sick Children, Canada; The SickKids Research Institute, Canada; University of Toronto, Canada. Electronic address: risto.filippi@sickkids.ca.

²Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.

³Institute of Biomedical Engineering, Boğaziçi University, Istanbul, Turkey; Cortechs Labs, Inc., San Diego, USA.

⁴Faculty of Health, University of Canterbury, Christchurch, New Zealand. Electronic address: richard.watts@canterbury.ac.nz.

PubMed PMC DOI PDF

Abstract

Many neuropsychiatric disorders demonstrate sex-based differences in their prevalence, onset age, and phenotypic presentation. The neuroanatomic and neurophysiologic substrates that underpin these sex differences are not fully understood. Animal studies have demonstrated sex differences in neuronal, dendritic, and glial microstructure. Restriction Spectrum Imaging (RSI) is an advanced diffusion MR…

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