Diagnostic performance of plasma pTau217 in genetically admixed South American populations

Diagnostic performance of plasma pTau217 in genetically admixed South American populations.

Pamela V Martino-Adami¹, Joice Coutinho de Alvarenga^2,3,4, Pilar Freccero⁵, Hanna Huber⁶, Julio Fernandez⁵, Ivonne Carolina Bolaños Burgos^2,3,4, Maria Barbara Postillone⁵, Gabriela Tomé Oliveira Engelmann^2,3,4, Ines Mintz^5,7, Marco Aurelio Romano Silva^2,3,8, Nancy Medel^5,7, Erika de Oliveira Hansen^2,3,4, Julieta Lisso^5,7, Natalia Dias Silva^2,4, Andréa Teixeira Carvalho⁹, Nicolás Irureta^5,7, Débora Marques de Miranda^2,3,8, Mariana Vallejo-Azar^5,7, Luiz Armando Cunha de Marco^2,3,8, Stefanie Heilmann-Heimbach¹⁰, Jonas Jardim de Paula^2,3,4, Silvia Kochen⁵, Rafaela Teixeira de Ávila^2,3,4, Patricia Solis⁵, Anja Schneider^6,11, Paula Gonzalez⁵, Bernardo de Mattos Viana^2,3,4, Maria Carolina Dalmasso⁵, Maria Aparecida Camargos Bicalho^12,13,14, Alfredo Ramírez^{15,16,17,18,19}

¹Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

²Reference Center for the Elderly, University Hospital of the Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.

³Molecular Medicine Postgraduate Program, Faculty of Medicine, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.

⁴Older Adult Psychiatry and Psychology Extension Program (PROEPSI), Faculty of Medicine, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.

⁵Studies in Neuroscience and Complex Systems Unit (ENyS-CONICET-HEC-UNAJ), Florencio Varela, Argentina.

⁶German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.

⁷Asistencia Medica Integral, Hospital El Cruce, Florencio Varela, Argentina.

⁸Neurotec R National Institute of Science and Technology (INCT-Neurotec R), Faculty of Medicine, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.

⁹Fundação Oswaldo Cruz (Fiocruz), Instituto René Rachou, Minas Gerais, Brasil.

¹⁰Institute of Human Genetics, University Hospital of Bonn & University of Bonn, Bonn, Germany.

¹¹Department of Old Age Psychiatry and Cognitive Disorders, University Hospital Bonn, Bonn, Germany.

¹²Reference Center for the Elderly, University Hospital of the Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil. macbicalho@ufmg.br.

¹³Molecular Medicine Postgraduate Program, Faculty of Medicine, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil. macbicalho@ufmg.br.

¹⁴Older Adult Psychiatry and Psychology Extension Program (PROEPSI), Faculty of Medicine, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil. macbicalho@ufmg.br.

¹⁵Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. alfredo.ramirez-zuniga@uk-koeln.de.

¹⁶German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany. alfredo.ramirez-zuniga@uk-koeln.de.

¹⁷Department of Old Age Psychiatry and Cognitive Disorders, University Hospital Bonn, Bonn, Germany. alfredo.ramirez-zuniga@uk-koeln.de.

¹⁸Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany. alfredo.ramirez-zuniga@uk-koeln.de.

¹⁹Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX, USA. alfredo.ramirez-zuniga@uk-koeln.de.

Abstract

Plasma pTau217 is a leading biomarker for Alzheimer's disease, but evidence from genetically admixed populations in low- and middle-income countries remains limited. We evaluated the diagnostic performance of pTau217 and pTau217/Aβ42 measured using Simoa technology in memory-clinic cohorts from Brazil (Cog-Aging-Study, n = 353) and Argentina (GeNED.ar, n = 134). Here we show that both biomarkers a…

Abstract

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