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Peer-Reviewed Publication
Curr Biol2026September 3, 2026Journal Article

Networks of sexually dimorphic neurons that regulate social behaviors in Drosophila.

Gerald M Rubin1, Claire M Managan2, Marisa Dreher2, Elizabeth Kim2, Scott W Miller2, Kaitlyn N Boone2, Alice A Robie2, Adam L Taylor2, Kristin Branson2, Catherine E Schretter2, Adriane G Otopalik3
1Janelia Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA; FlyEM Project Team, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA. Electronic address: rubing@janelia.hhmi.org.
2Janelia Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA.
3Janelia Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA. Electronic address: otopalika@janelia.hhmi.org.
PubMed DOI

Abstract

Neural mechanisms underlying sexually dimorphic social behaviors remain enigmatic in most species. In Drosophila, sexually dimorphic pC1/pC1x neurons have been described as a site of sensory integration that regulates mating and aggressive behaviors. We show that the male pC1/pC1x population resides in an expansive and highly intertwined male-specific network that is poised to regulate social beha…

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