Peer-Reviewed Publication
Nature2026September 2, 2026Journal Article
Intracellular complement factor H protects neurons during CNS inflammation.
Christina Mayer1,2, Marcel S Woo1,2, Jana K Sonner1,2, Lars Binkle-Ladisch1,2, Felix Fischbach1,2, Patricia Sekol3, Matthew D Smith4, Fernando Lucas-Ruiz1,2,5, Darwin Manteufel1,2, Kuno M-J Mattern1,2, Lena Kristina Pfeffer1,2, Yubing Guo6,7, Bente Siebels8, Albert Miguela1,2,9, Vanessa Vieira1,2, Nina Meurs1,2, Simone Bauer1,2, Sophia Schwarz3, Sonia Wulf10, Anne Katrin Mühlig6,7,11,12, Jan Broder Engler1,2, Marcus Conrad13,14, Florence M Bareyre15, Thorsten Wiech10, Susanne Krasemann16, Markus Glatzel16, Peter F Zipfel17, Tilo Freiwald6,7, Peter A Calabresi4, Lucas Schirmer3,18,19,20, Manuel A Friese21,22
1Institute of Neuroimmunology and Multiple Sclerosis (INIMS), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
2Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
3Division of Neuroimmunology, Department of Neurology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
4Departments of Neurology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
5Group of Experimental Ophthalmology, Instituto Murciano de Investigación Biosanitaria Virgen de la Arrixaca (IMIB-Arrixaca) and Ophthalmology Department, Universidad de Murcia, Murcia, Spain.
6III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
7Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
8Section Mass Spectrometry and Proteomics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
9Neurodegeneration and Neuroinflammation Group, Girona Biomedical Research Institute (IDIBG-CERCA), Salt, Spain.
10Institute of Pathology, Nephropathology Section, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
11University Children's Hospital, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
12University Children's Research@Kinder-UKE, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
13Institute of Metabolism and Cell Death, Molecular Targets and Therapeutics Center, Helmholtz Munich, Neuherberg, Germany.
14Translational Redox Biology, Technical University of Munich (TUM), TUM Natural School of Sciences, Garching, Germany.
15Institute of Clinical Neuroimmunology, University Hospital LMU Munich, Munich, Germany.
16Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
17Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany.
18Mannheim Center for Translational Neuroscience, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
19Mannheim Institute for Innate Immunoscience, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
20Interdisciplinary Center for Neurosciences, Heidelberg University, Heidelberg, Germany.
21Institute of Neuroimmunology and Multiple Sclerosis (INIMS), University Medical Center Hamburg-Eppendorf, Hamburg, Germany. manuel.friese@zmnh.uni-hamburg.de.
22Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany. manuel.friese@zmnh.uni-hamburg.de.
Abstract
Neurodegeneration is a major driver of disability in multiple sclerosis (MS), the most common chronic inflammatory disease of the central nervous system (CNS)1. Retinal ganglion cells (RGCs), a heterogeneous neuronal population in the eye, undergo degeneration in MS and provide a model to study neuronal subtype-specific resilience to inflammatory injury2. However, the neuron-intrinsic mechanisms u…
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