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Peer-Reviewed Publication
Cancer Discov2026September 2, 2026Journal Article

Functionally active lymphoid aggregates correlate with improved prognosis in brain metastases.

Noor E Nader1, Alexandra R Glathar2, Elaine V Byrnes3, Marion Joy4, Tengziyi Ge5, Andrew Elliott6, Ryan Jaehne6, Caroline J Layding7, Curtis Mamoru Tatsuoka3, Gabriel Sica8, Rajesh Acharya4, Riyue Bao1, Anthony R Cillo9, Aron Y Joon10, Swaminathan Kumar11, Rami B Yanes3, Xiancheng Wu3, Luisa M Solis Soto10, Claudio A Arrechedera10, Auriole Tamegnon10, Beatriz Sanchez-Espiridion12, Hussein A Tawbi12, Elizabeth M Burton10, Michael A Davies10, Thomas M Pearce9, Timothy F Burns13, Laura P Stabile9, Xiaoran Zhang14, Tullia C Bruno2
1University of Pittsburgh Pittsburgh United States.
2University of Colorado Boulder Pittsburgh, PA United States.
3University of Pittsburgh United States.
4UPMC Hillman Cancer Center Pittsburgh, PA United States.
5University of Pittsburgh Medical Center United States.
6Caris Life Sciences (United States) Phoenix, AZ United States.
7University of Pittsburgh Pittsburgh, Pennsylvania United States.
8Emory University Atlanta, GA United States.
9University of Pittsburgh Pittsburgh, PA United States.
10The University of Texas MD Anderson Cancer Center Houston, TX United States.
11UT MD Anderson Cancer Center Houston, Texas United States.
12The University of Texas MD Anderson Cancer Center Houston, Texas United States.
13The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute Columbus, Ohio United States.
14Sutter Health San Francisco United States.
PubMed DOI

Abstract

B cells and their cellular neighborhoods, i.e., lymphoid aggregates (LAs) and tertiary lymphoid structures (TLS), have not been extensively studied in melanoma brain metastases (BM) or lung adenocarcinoma (LUAD) BM, despite their prognostic value and role in immunotherapeutic responses. In this study, we evaluated the prognostic benefit and heterogeneity of B cell infiltration and LA formation in…

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