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Peer-Reviewed Publication
J Genet Couns2026;35(5):e70285.October 1, 2026Journal Article

Understanding Barriers and Motivators of Familial Hypercholesterolemia Genetic Testing: Insights From the Singapore Public.

Dorothy S R Quek1, Ruoyu Yin1, Frederick H F Chan2, Ashna Nastar3, Joanne Ngeow1,4, Sharon Pek5, Julian Savulescu6,7, Tavintharan Subramaniam5,8, Konstadina Griva1
1Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
2Department of Social Work and Social Administration, The University of Hong Kong, Hong Kong SAR.
3Division of Endocrinology, Alexandra Hospital, Singapore.
4Cancer Genetics Service, Division of Medical Oncology, National Cancer Centre, Singapore.
5Clinical Research Unit, Khoo Teck Puat Hospital, Singapore.
6Uehiro Oxford Institute, University of Oxford, Oxford, UK.
7Centre for Biomedical Ethics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
8Diabetes Centre Admiralty Medical Centre, Division of Endocrinology, Department of Medicine, Khoo Teck Puat Hospital, Singapore.
PubMed DOI

Abstract

Familial hypercholesterolemia (FH) is a common monogenic disorder associated with elevated low-density lipoprotein cholesterol and premature cardiovascular disease. Despite Singapore's high FH prevalence and the launch of the National FH Genetic Testing Programme in 2025, uptake remains suboptimal. This study aimed to assess public attitudes, perceptions, and willingness to undergo FH genetic test…

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