Genome mining reveals an architecturally expanded pyoluteorin-associated biosynthetic gene cluster and a divergent flavin-dependent halogenase-like sequence in deep-sea Pseudomonas Aeruginosa from the Gulf of Guinea.

Sunday Babatunde Akinde^1,2,3, Emmanuel Sunday Fajoyegbe^4,5, Oluwaseyi Paul Olaniyan^6,7,5, Omokaro Obire⁸, Adedolapo Aishat Salami^4,5, Ademola Ayodele Adesoye^4,5, Waidi Folorunso Sule^4,5, Elijah Kolawole Oladipo^9,10, Olabisi Olaniyi Ojo¹¹

¹Department of Microbiology, Osun State University, Osogbo, Nigeria. akindesb@uniosun.edu.ng.

²Multidisciplinary Research Laboratory, Osun State University, Osogbo, Nigeria. akindesb@uniosun.edu.ng.

³Microbial Biotechnology and One Health Research Laboratory, Osun State University, Osogbo, Nigeria. akindesb@uniosun.edu.ng.

⁴Department of Microbiology, Osun State University, Osogbo, Nigeria.

⁵Microbial Biotechnology and One Health Research Laboratory, Osun State University, Osogbo, Nigeria.

⁶Department of Biochemistry, Osun State University, Osogbo, Nigeria.

⁷Multidisciplinary Research Laboratory, Osun State University, Osogbo, Nigeria.

⁸Department of Microbiology, Rivers State University, Port-Harcourt, Nigeria.

⁹Division of Genome and Molecular Sciences, Helix Biogen Institute, Ogbomoso, Nigeria.

¹⁰Department of Microbiology, Laboratory of Molecular Biology, Immunology and Bioinformatics, Adeleke University, Ede, Nigeria.

¹¹Department of Natural Sciences, Albany State University, Albany, USA.

PubMed DOI

Abstract

BACKGROUND: Marine deep-sea environments harbour microorganisms with extraordinary biosynthetic potential, yet their secondary metabolite repertoires remain largely uncharacterised. RESULTS: This study reports the isolation, phenotypic characterisation, and whole-genome analysis of Pseudomonas aeruginosa strain E1, recovered from deep Atlantic seawater (Gulf of Guinea, ~2500 m depth), which exhib…

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