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Pediatr Dermatol2026September 1, 2026Case Reports

Pediatric Non-Neural Granular Cell Tumor With Unexpected Molecular Identity: A Case That Challenges Classification.

Grace S Saglimbeni1, Eduardo Zambrano2,3, Sierra Wolter4,5, Nawal Merjaneh3,6, Kristian Schafernak2,3, Brian Keehn7, Peaches Ulrich8, Maria Epino1, Danielle Vargas de Stefano2,3,5
1Creighton University School of Medicine, Phoenix, Arizona, USA.
2Division of Pathology and Laboratory Medicine, Phoenix Children's Hospital, Phoenix, Arizona, USA.
3Department of Child Health, University of Arizona College of Medicine-Phoenix, Phoenix, Arizona, USA.
4Division of Dermatology, Phoenix Children's Hospital, Phoenix, Arizona, USA.
5Department of Dermatology, University of Arizona College of Medicine-Tucson, Tucson, Arizona, USA.
6Center for Cancer and Blood Disorders, Phoenix Children's Hospital, Phoenix, Arizona, USA.
7Division of Radiology, Phoenix Children's Hospital, Phoenix, Arizona, USA.
8Caris Life Sciences, Phoenix, Arizona, USA.
PubMed DOI

Abstract

A 7-year-old boy presented with a 3-year history of a slow-growing superficial cutaneous nodule adjacent to the right acromion, with subsequent development of a second subcutaneous mass near the right scapula. Biopsy of the primary lesion revealed a rare non-neural granular cell tumor (NNGCT) lacking S100 expression, distinguishing it from classic granular cell tumors (GCT), and molecular profilin…

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