IL-5 Biology and Eosinophil Regulation: Advances, Resistance Pathways and Future Directions.

V Patella¹, C Nicoletta¹, F Ferrara¹, O Inglese¹, A Giuliano²

¹Department of Internal Medicine and Division of Allergy and Clinical Immunology ASL Salerno, "Santa, Maria Della Speranza" Hospital, Battipaglia, Italy.

²Simple Departmental Operating Unit of Toxicology Laboratory, ASL Salerno, Salerno, Italy.

PubMed DOI

Abstract

Interleukin-5 (IL-5) is a central regulator of eosinophil differentiation, maturation, trafficking, activation and survival, and therapeutic targeting of the IL-5/IL-5 receptor alpha pathway has substantially changed the management of severe eosinophilic asthma and other eosinophil-associated disorders. However, clinical responses to anti-IL-5 and anti-IL-5Rα biologics remain heterogeneous, and pe…

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