Performance and Projected Impact of Synovial Fluid Polymerase Chain Reaction Testing for Patients Evaluated for Septic Arthritis.

Mark T Steele¹, Amy M Stubbs¹, Anusha Krishnadasan², Laurie Kemble¹, Ruoyu Li², William R Mower², Joseph Liao², Gregory J Moran², David A Talan²,

¹University Health/University of Missouri-Kansas City School of Medicine, Department of Emergency Medicine, Kansas City, MO, United States.

²Olive View-UCLA Education and Research Institute and the David Geffen School of Medicine, Department of Emergency Medicine, University of California, Los Angeles, CA, United States.

PubMed DOI

Abstract

BACKGROUND: Septic arthritis is an infectious disease emergency. Diagnosis is limited by low sensitivity of synovial fluid cell count and Gram stain and delayed culture results. The impact of PCR testing on clinical care of patients suspected of septic arthritis is unknown. METHODS: We conducted a prospective, observational study (2021-23) at nine US EDs of adults evaluated for septic arthritis w…

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