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Peer-Reviewed Publication
J Am Coll Cardiol2026August 29, 2026Journal Article

Stent Retriever Thrombectomy in Patients With Myocardial Infarction The Open-label, Multicenter NATURE Superiority trial.

Marco Valgimigli1, Enrico Frigoli2, Antonio Landi3, Marco Covani3, Simone Biscaglia4, Florim Cuculi5, Andrea Erriquez4, Matthias Bossard5, Antonio Mangieri6, Martijn Meuwissen7, Juan F Iglesias8, Giuseppe Sangiorgi9, Erik Lipšic10, Jacopo Andrea Oreglia11, Jonas D Häner12, Valeria Paradies13, Anna Giulia Pavon3, Laura Anna Leo3, Felice Gragnano14, Federico Fuentes15, Vincenzo Viccaro3, Antonio Colombo6, Sanda Branca16, Sergio Leonardi17, Hector M Garcia-Garcia15,
1Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale (EOC); Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland. Electronic address: marco.valgimigli@eoc.ch.
2Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale (EOC); CTU Bern, University of Bern, Bern, Switzerland.
3Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale (EOC).
4Cardiology Unit, Azienda Ospedaliera Universitaria di Ferrara, Italy.
5Division of Cardiology, Heart Center, Luzerner Kantonsspital, Lucerne, Switzerland.
6Division of Cardiology, IRCCS Humanitas Research Hospital, Rozzano-Milan, Italy.
7Department of Cardiology, Amphia Hospital, Breda, the Netherlands.
8Department of Cardiology, Geneva University Hospitals, Geneva, Switzerland.
9Division of Cardiology, University of Rome "Tor Vergata", Rome, Italy.
10Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
11Division of Cardiology, De Gasperis Cardio Center, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
12Department of Cardiology, Bern University Hospital, Inselspital, University of Bern, Bern, Switzerland.
13Department of Cardiology, Maasstad Hospital, Rotterdam, the Netherlands.
14Department of Translational Medical Sciences, University of Campania Luigi Vanvitelli, Caserta, Italy; Division of Clinical Cardiology, AORN Sant'Anna e San Sebastiano, Caserta, Italy.
15Section of Interventional Cardiology, MedStar Health, Washington, DC, USA.
16Data Center, Swiss Transplant Cohort Study, University of Basel, Switerland.
17University of Pavia and Fondazione IRCCS Policlinico San Matteo, Italy (S Leonardi MD, MHS).
PubMed DOI

Abstract

BACKGROUND: Patients with myocardial infarction and large thrombus burden face greater infarct size and higher mortality, yet no effective therapy exists for this high-risk subgroup. OBJECTIVES: To investigate the effects of stent-retriever thrombectomy in addition to conventional percutaneous coronary intervention (PCI) versus conventional PCI alone on infarct size. METHODS: In this open-label,…

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