The Molecular and Immunological Landscape in Nasopharyngeal Carcinoma (NPC) Differs by Somatostatin Receptor 2 (SSTR2) Expression.

Dara Bracken-Clarke¹, Elisabetta Xue¹, Harris Krause², Tolulope Adeyelu², Mark G Evans², Dilara Akbulut³, Martha Quezado³, Nishant Gandhi², Alex Farrell², Heloisa P Soares⁴, Emil Lou⁵, Minh Phan⁶, Rusha Patel⁶, Ari M Vanderwalde², Andrew Elliott², Conor E Steuer⁷, Nabil F Saba⁷, Daniel J Lubin⁷, Nyall R London^8,9, James L Gulley¹, Charalampos S Floudas¹

¹Center for Immuno-Oncology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

²CARIS Life Sciences, Phoenix, Arizona, USA.

³Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

⁴Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA.

⁵University of Minnesota, Minneapolis, Minnesota, USA.

⁶Stephenson Cancer Center - University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.

⁷Winship Cancer Institute of Emory University, Atlanta, Georgia, USA.

⁸Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

⁹Sinonasal and Skull Base Tumor Program, Surgical Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

PubMed DOI

Abstract

Somatostatin receptor 2 is expressed in nasopharyngeal carcinoma (NPC). We report genomic and transcriptomic analysis results of 163 NPC cases, demonstrating that somatostatin receptor 2 (SSTR2) gene expression in EBV-positive and in EBV-negative NPC correlated with genomic alterations and an inflamed microenvironment. Median SSTR2 expression was 6.52 transcripts per million (TPM), ranging from 0.…

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