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Physiol Rep2026;14(17):e71088.September 1, 2026Journal Article

Exacerbated expansive vascular remodeling due to disturbed flow in male mice overexpressing protein disulfide isomerase-A1.

Júlia Martins Felipe de Souza1, Tiphany Coralie De Bessa1, Amanda de Almeida Silva2, Carolina Gonçalves Fernandes3, Leonardo Yuji Tanaka1,4, Francisco Rafael Martins Laurindo1
1Vascular Biology Lab (LVascBio), LIM-64, Heart Institute, University of São Paulo School of Medicine (FMUSP), São Paulo, São Paulo, Brazil.
2Laboratory of Hypertension, Heart Institute (InCor), University of São Paulo School of Medicine, São Paulo, São Paulo, Brazil.
3Santa Casa de São Paulo, School of Medical Sciences (FCMSCSP), São Paulo, São Paulo, Brazil.
4Redox Mechanobiology Laboratory, Federal University of São Paulo (UNIFESP), School of Medicine, São Paulo, São Paulo, Brazil.
PubMed DOI

Abstract

Vascular expansive remodeling is involved in atherosclerosis/restenosis; however, its mechanisms need further investigation. Protein-disulfide isomerase (PDIA1), a redox chaperone from the endoplasmic reticulum and cell surface, supports vascular smooth muscle mechanoadaptation. Vascular injury repair reportedly associates with marked PDIA1 overexpression, while PDIA1 inhibition limits expansive r…

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