Health AI Central
Peer-Reviewed Publication
BMJ Open2026;16(8):e114585.August 28, 2026Journal Article

Speech-based relapse prediction in psychosis using explainable AI: Protocol for the international multicentre observational TRUSTING study.

Roya Melanie Hüppi1,2, Lucía Bautista1, Giacomo Cecere1,2, Wolfgang Omlor1,2, Sandra Anna Just3,4, Sanne Koops5, Musarrat Hussain6, Enrico Tedeschi6, Stephan Benke-Bruderer7, Emre Bora8,9, John Lyne10, Stefan Kaiser11, Elodie Sprüngli-Toffel11, Matthias Kirschner11, Karl Øyvind Mikalsen3,12, Lars Ailo Bongo6, Erik Van der Eycken13, Filip Španiel14, Brita Elvevag3,12, Iris Ec Sommer5, Wolfram Hinzen15,16, Philipp Homan17,2
1Department of Adult Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Zurich, Switzerland.
2Faculty of Medicine, University of Zurich, Zurich, Switzerland.
3Department of Clinical Medicine, UiT The Arctic University of Norway, Tromsø, Norway.
4Department of Psychiatry and Neurosciences, Campus Charité Mitte, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Charité - Universitätsmedizin Berlin, Berlin, Germany.
5Department of Neuroscience, University Medical Centre Groningen, Groningen, Netherlands.
6Department of Computer Science, UiT The Arctic University of Norway, Tromsø, Norway.
7Clinical Trials Center, University Hospital Zurich, Zurich, Switzerland.
8Department of Psychiatry, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey.
9Department of Neurosciences, Health Sciences Institute, Dokuz Eylul University, Izmir, Turkey.
10Royal College of Surgeons in Ireland, Dublin, Ireland.
11Adult Psychiatry Division, Department of Psychiatry, Geneva University Hospitals, Geneva, Switzerland.
12Norwegian Centre for Clinical Artificial Intelligence, University Hospital of North Norway, Tromsø, Norway.
13Global Alliance of Mental Illness Advocacy Networks-Europe (GAMIAN-Europe), Brussels, Belgium.
14National Institute of Mental Health, Klecany, Czech Republic.
15Department of Translation and Language Sciences, Universitat Pompeu Fabra, Barcelona, Spain.
16Institut Català de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.
17Department of Adult Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Zurich, Switzerland philipp.homan@bli.uzh.ch.
PubMed DOI

Abstract

INTRODUCTION: The course of psychotic disorders typically involves relapses. Early warning signs vary between individuals and are difficult to detect in clinical practice, especially in outpatient settings. Speech provides a quantitative clinical marker for detecting such early warning signs. The EU Horizon project TRUSTING (A TRUSTworthy speech-based AI monitoring system for the prediction of rel…

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