Unveiling crosstalk regulations within the polyamine pathway and between polyamine and purine pathways in Aedes aegypti females.

Jun Isoe¹, Thomas D Horvath², Vlad Orlovsky³, Paula Castillo Bravo⁴, Stacy Mazzalupo⁵, Patricia Y Scaraffia⁶

¹Department of Entomology, The University of Arizona, Tucson, AZ 85721, USA.

²Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA; Department of Pathology, Texas Children's Hospital, Houston, TX 77030, USA; Microbiome Center - Texas Children's Research Institute, Texas Children's Hospital, Houston, TX 77030, USA; Department of Pharmacy Practice and Translational Research, College of Pharmacy, University of Houston, Houston, TX 77030, USA.

³Helix Chromatography, Prospect Heights, IL, 60070, USA.

⁴Department of Tropical Medicine and Infectious Disease, Vector-Borne Infectious Disease Research Center, Celia Scott Weatherhead School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA.

⁵Bruker Spatial Genomics, Inc., San Jose, CA, USA.

⁶Department of Tropical Medicine and Infectious Disease, Vector-Borne Infectious Disease Research Center, Celia Scott Weatherhead School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA. Electronic address: pscaraff@tulane.edu.

PubMed DOI

Abstract

We previously demonstrated that ornithine decarboxylase (ODC) deficiency critically impairs nitrogen metabolism and survival in Aedes aegypti. To further examine the role of the polyamine pathway in Ae. aegypti nitrogen metabolism, we evaluated the expression of three additional genes encoding proteins involved in the biosynthetic pathway: S-adenosylmethionine decarboxylase, spermidine synthase (S…

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