Ribonucleotide Reductase Inhibition Triggers Ferroptosis in Genetically Defined Subsets of Non-Small Cell Lung Cancer.

Utsav Sen¹, Dalia Natour², Subhamoy Chakraborty³, Elisa Gobbini², Chih-Wei Fan¹, Calvin Koelbel², Andrew Elliott⁴, Ari M Vanderwalde⁵, Hossein Borghaei⁶, Balazs Halmos⁷, Deniz Demircioglu¹, Dan Hasson⁸, Nishant Gandhi⁴, Triparna Sen²

¹Icahn School of Medicine at Mount Sinai New York, New York United States.

²The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute Columbus, Ohio United States.

³Icahn School of Medicine at Mount Sinai New York, NY United States.

⁴Caris Life Sciences (United States) Phoenix, AZ United States.

⁵Caris Life Sciences (United States) Los Angeles, CA United States.

⁶Fox Chase Cancer Center Philadelphia, PA United States.

⁷Montefiore Medical Center Bronx, NY United States.

⁸Icahn School of Medicine at Mount Sinai New York United States.

PubMed DOI

Abstract

Non-small-cell lung cancer (NSCLC) is responsible for the majority of cancer-related mortality worldwide. Lung adenocarcinoma (LUAD) is the most common NSCLC subtype. Despite advances in targeted therapies, treatment resistance remains a critical challenge. Ribonucleotide reductase (RNR), a crucial enzyme in deoxyribonucleotide triphosphate (dNTP) biosynthesis, is frequently upregulated in cancer,…

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