Peer-Reviewed Publication
Acta Diabetol2026August 28, 2026Journal Article
Predictors of first-ever major adverse cardiovascular events in newly diagnosed type 2 diabetes: a 5-year prospective cohort study.
Carmine Gazzaruso1,2, Pietro Gallotti3, Colomba Falcone4,5, Livio Luzi6,7, Adriana Coppola8
1Department of Biomedical Sciences for Health, University of Milan, Milan, Italy. carmine.gazzaruso@unimi.it.
2Diabetes, endocrine-metabolic and vascular diseases Unit, University of Milan, Istituto Clinico Beato Matteo, Gruppo Ospedaliero San Donato, Clinico Beato Matteo - Corso Pavia 84, 27029, Vigevano, Italy. carmine.gazzaruso@unimi.it.
3Internal Medicine Unit, Istituto Clinico Beato Matteo, Gruppo Ospedaliero San Donato, Vigevano, Italy.
4Centro Interdipartimentale di Medicina Molecolare per la Diagnosi e la Cura delle Malattie Cardiovascolari e Metaboliche (CIRMC), University of Pavia, Pavia, Italy.
5Cardiology Unit, Istituto di Cura Città di Pavia, Gruppo Ospedaliero San Donato, Pavia, Italy.
6Department of Biomedical Sciences for Health, University of Milan, Milan, Italy.
7Department of Endocrinology, IRCCS Multimedica, Milan, Italy.
8Diabetes, endocrine-metabolic and vascular diseases Unit, University of Milan, Istituto Clinico Beato Matteo, Gruppo Ospedaliero San Donato, Clinico Beato Matteo - Corso Pavia 84, 27029, Vigevano, Italy.
Abstract
AIMS: Cardiovascular risk stratification at the time of type 2 diabetes diagnosis remains challenging. We evaluated the incidence and baseline predictors of first-ever major adverse cardiovascular events (MACE) in patients with newly diagnosed type 2 diabetes without overt complications.
METHODS: We conducted a prospective cohort study of 937 consecutive adults with newly diagnosed type 2 diabete…
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