Multistrain probiotics modulate tau pathology and preserve visuospatial cognition in early cognitive impairment: A double-blind, randomized, placebo-controlled trial.

Eun Hyun Seo^1,2, Sarang Kang³, Seung-Gon Kim⁴, Ja-Hae Kim⁵, Hye-Jung Yoon⁶, Kyu Yeong Choi¹, Hyung-Jun Yoon⁴, Kun Ho Lee^1,7,8, Kang-Ho Choi⁶

¹Gwangju Alzheimer's Disease and Related Dementia Cohort Research Center, Chosun University, Gwangju, Republic of Korea.

²Premedical Science, College of Medicine, Chosun University, Gwangju, Republic of Korea.

³BK21-Four Educational Research Group for Age-Associated Disorder Control Technology, Chosun University, Gwangju, Republic of Korea.

⁴Department of Neuropsychiatry, Chosun University Hospital, Gwangju, Republic of Korea.

⁵Department of Nuclear Medicine, Chonnam National University Hospital and Medical School, Gwangju, Republic of Korea.

⁶Department of Neurology, Chonnam National University Hospital and Medical School, Gwangju, Republic of Korea.

⁷Department of Biomedical Science, Chosun University, Gwangju, Republic of Korea.

⁸Korea Brain Research Institute, Daegu, Republic of Korea.

PubMed DOI

Abstract

BackgroundThe gut-brain axis is increasingly implicated in Alzheimer's disease (AD) pathogenesis.ObjectiveTo investigate whether a multistrain probiotic supplement is associated with changes in AD-related plasma biomarkers and cognitive function in older adults with early cognitive impairment.MethodsIn this randomized, double-blind, placebo-controlled trial, eighty-seven participants from the Gwan…

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