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Clin Transl Radiat Oncol2026;61101257.November 1, 2026Journal Article

Artificial Intelligence impact on decision-making regarding short-term ADT with prostate radiotherapy: ASTuTE clinical trial interim results.

Eric Wegener1,2, Michael Ng3,4, Mario Guerrieri3, Timothy N Showalter5,6, Jeremy de Leon7, Sagar Ramani8, Marcus Dreosti9, Tee Lim10,11, Bradley Wong12, Annie Ho7, Michael Chao13, Zachary Wilczynski5, Peter Chong14, Scott McClintock15, Darren Foreman16, Matthew Brown17, Stephen McCombie17, Kevin McMillan18, Marcus Handmer19, Mark Frydenberg20, Lih-Ming Wong21, Dickon Hayne10,11, John Yaxley22, Phillip Stricker23, Jarad Martin1,2
1GenesisCare Lake Macquarie Private Hospital, 3 Sydney St Lake Macquarie, Gateshead, NSW 2290, Australia.
2University of Newcastle, Callaghan, NSW 2308, Australia.
3GenesisCare St Vincent's Hospital, 41 Victoria Parade, Fitzroy, VIC 3065, Australia.
4Department of Medicine, University of Melbourne, Australia.
5Artera Inc., Los Altos, CA, USA.
6University of Virginia, Department of Radiation Oncology, Charlottesville, VA, USA.
7GenesisCare St Vincent's Hospital, Level A, 438 Victoria Street, Darlinghurst, NSW 2010, Australia.
8GenesisCare John Flynn Private Hospital, 42 Inland Drive, Tugun, QLD 4224, Australia.
9GenesisCare Kurralta Park, Tennyson Centre, 520 South Road, Kurralta Park, SA 5037, Australia.
10Fiona Stanley Hospital, 102-118 Murdoch Drive, Murdoch, WA 6150, Australia.
11Medical School, The University of Western Australia, Perth, Australia.
12GenesisCare Buderim, 10 King Street, Buderim, QLD 4556, Australia.
13GenesisCare Ringwood Private Hospital, 36 Mount Dandenong Road, Ringwood East, VIC 3135, Australia.
14Lake Macquarie Urology, Level 3, Suite 2/20 Smart St, Charlestown, NSW 2290, Australia.
15Gold Coast Private Hospital, Level 3, 123 Nerang St, Southport, QLD 4215, Australia.
16South Terrace Urology, 326 South Tce, Adelaide, SA 5000, Australia.
17St John of God Wexford Medical Centre, 3 Barry Marshall Parade, Murdoch 6150, WA, Australia.
18Knox Private Hospital, 262 Mountain Hwy, Wantirna, VIC 3152, Australia.
19John Hunter Hospital, Department of Urology, Lookout Road, New Lambton, NSW 2305, Australia.
20Australian Urology Associates, Ground Floor, 322 Glenferrie Rd, Malvern, VIC 3144, Australia.
21Melbourne Urology Group, Suite 2, 141 Grey Street, East Melbourne, Australia.
22Wesley Urology Clinic, Suite 42, Level 4, Wesley Medical Centre, 40 Chasely Street, Auchenflower, QLD 4066, Australia.
23St Vincent's Hospital Sydney, Darlinghurst, New South Wales, Australia.
PubMed PMC DOI PDF

Abstract

This interim analysis of a multicentre implementation trial (n = 200) evaluated a multimodal artificial intelligence biomarker's impact on shared short-term androgen deprivation therapy (ST-ADT) decisions in intermediate-risk prostate cancer (IR-PC). Biomarker testing altered 27.5% (CI: 21.4-34.2%) of final decisions. ST-ADT use significantly decreased: 70.3% (CI: 58.5-80.3%) of patients initially…

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