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Peer-Reviewed Publication
Eur J Nucl Med Mol Imaging2026August 28, 2026Journal Article

Integrated 18F-NOTA-FAPI-04 PET/MRI for quantitative assessment of disease activity in thyroid-associated ophthalmopathy.

Xueqian Yang1, Linyang Gan2, Ximin Shi1, Meiqi Wu1, Enhui Li3, Yuke Zhang1, Zhixin Hao1, Zhenghai Huang1, Haiqun Xing4, Xiaowei Liu2, Li Huo5
1Department of Nuclear Medicine, Beijing Key Laboratory of Molecular Targeted Radiopharmaceutical Development and Translational Application, State Key Laboratory of Complex, Severe, and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100730, China.
2Department of Ophthalmology, Peking Union Medical College Hospital, Beijing Key Laboratory of Fundus Diseases Intelligent Diagnosis & Drug/Device Development and Translation, Key Laboratory of Ocular Fundus Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China.
3Shanghai United Imaging Healthcare Co., Ltd., 201807, Shanghai, China.
4Department of Nuclear Medicine, Beijing Key Laboratory of Molecular Targeted Radiopharmaceutical Development and Translational Application, State Key Laboratory of Complex, Severe, and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100730, China. 15801255152@163.com.
5Department of Nuclear Medicine, Beijing Key Laboratory of Molecular Targeted Radiopharmaceutical Development and Translational Application, State Key Laboratory of Complex, Severe, and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100730, China. huoli@pumch.cn.
PubMed DOI

Abstract

PURPOSE: This study aimed to evaluate the value of integrated 18F-NOTA-FAPI-04 PET/MRI for CAS-defined clinical activity assessment in thyroid-associated ophthalmopathy (TAO) by investigating the correlation between PET- and multi-parametric MRI-derived features and their predictive performance. METHODS: A total of 33 TAO participants were prospectively enrolled and underwent intergrated 18F-NOTA…

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