Health AI Central
Peer-Reviewed Publication
Virchows Arch2026August 28, 2026Journal Article

Deep learning augmented pathological grading and intraductal carcinoma of the prostate signatures improve recurrence prediction after intensity-modulated radiation therapy.

Mami Takadate1,2,3, Rihito Aizawa4, Yasushi Numata2, Atsushi Marugame2, Jyunya Iwazaki5, Masao Ueki2,6, Takayuki Takahashi1,2, Kaori Ono1,2, Kotaro Tsutsumi2,7, Hayato Takeda2,3, Jun Akatsuka2,3, Yuki Endo3, Yuka Toyama3, Ryuji Ohashi8, Akira Shimizu2,9, Go Kimura2,3, Hironori Haga10, Takashi Kobayashi11, Yukihiro Kondo2,3, Takashi Mizowaki4, Yoichiro Yamamoto12,13,14,15, Toyonori Tsuzuki16,17
1Mathematical Intelligence for Medicine, Graduate School of Medicine, Tohoku University, Miyagi, 980-8575, Japan.
2Biomedical Spatial Science Team, RIKEN Center for Advanced Intelligence Project, Tokyo, 103-0027, Japan.
3Department of Urology, Nippon Medical School, Tokyo, 113-8603, Japan.
4Department of Radiation Oncology and Image-Applied Therapy, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan.
5Department of Artificial Intelligence and Medical Science, Graduate School of Medicine, Tohoku University, Miyagi, 980-8575, Japan.
6School of Information and Data Sciences, Nagasaki University, Nagasaki, 852-8521, Japan.
7Department of Neurology, University of California, Irvine, Orange, CA, 92868, USA.
8Department of Integrated Diagnostic Pathology, Nippon Medical School, Tokyo, 113-8603, Japan.
9Department of Analytic Human Pathology, Nippon Medical School, Tokyo, 113-8603, Japan.
10Department of Diagnostic Pathology, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan.
11Department of Urology, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan.
12Mathematical Intelligence for Medicine, Graduate School of Medicine, Tohoku University, Miyagi, 980-8575, Japan. yoichiro.yamamoto@riken.jp.
13Biomedical Spatial Science Team, RIKEN Center for Advanced Intelligence Project, Tokyo, 103-0027, Japan. yoichiro.yamamoto@riken.jp.
14Department of Urology, Nippon Medical School, Tokyo, 113-8603, Japan. yoichiro.yamamoto@riken.jp.
15Department of Artificial Intelligence and Medical Science, Graduate School of Medicine, Tohoku University, Miyagi, 980-8575, Japan. yoichiro.yamamoto@riken.jp.
16Biomedical Spatial Science Team, RIKEN Center for Advanced Intelligence Project, Tokyo, 103-0027, Japan. tsuzuki@aichi-med-u.ac.jp.
17Department of Surgical Pathology, Aichi Medical University Hospital, Aichi, 480-1195, Japan. tsuzuki@aichi-med-u.ac.jp.
PubMed DOI

Abstract

Locally advanced prostate cancer (PCa) is associated with a high recurrence rate even after curative treatment. We aimed to develop a precise risk model by integrating the status of intraductal carcinoma of the prostate (IDC-P) and the International Society of Urological Pathology Grade Group (ISUP GG) with deep learning (DL)-based grading to predict clinical recurrence after intensity-modulated r…

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