Development of a Claims-Based Algorithm and Validation Through Medical Chart Review to Identify Patients with Crohn's Disease-Related Fibrostenosis: A Retrospective Observational Study in the United States.

Yiran Zhang¹, William K Mountford², Jennifer Thompson², Ling Zhang², Maureen Carlyle¹, John White¹, Valery Walker¹, Florian Rieder^3,4

¹Value and Evidence Solutions, Optum, Eden Prairie, Minnesota, USA.

²Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut, USA.

³Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Ave. NC2, Cleveland, Ohio, 44195, USA. riederf@ccf.org.

⁴Department of Gastroenterology, Hepatology and Nutrition, Digestive Diseases Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA. riederf@ccf.org.

PubMed DOI

Abstract

INTRODUCTION: Fibrostenosis is a prevalent and clinically burdensome complication of Crohn's disease (CD), which is a type of inflammatory bowel disease. Identifying CD-related fibrostenosis (fsCD) in large datasets is challenging due to a lack of specific diagnostic codes. Manual chart review is the current standard, but it is not scalable for broader research. The objective of this study was the…

Create a free account to keep reading

Free members get 10 full research views every month across publications, clinical trials, FDA clearances, adverse events, and NIH grants. No credit card required.

Create Free Account Sign In

Want unlimited research access? See Pro plans

Data Accuracy Notice: Research intelligence on Health AI Central is aggregated from public sources (PubMed, ClinicalTrials.gov, FDA, NIH, CMS, and others) and refreshed nightly. Classifications and derived metrics are produced by automated methods described in our Methodology. We recommend verifying critical data points against the primary sources before making decisions.