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Peer-Reviewed Publication
Virchows Arch2026August 25, 2026Journal Article

Basal crypt dysplasia in inflammatory bowel disease: morphological quandaries, p53 immunohistochemistry and diagnostic pointers.

Kristen M Stashek1, Runjan Chetty2,3
1Perelman School of Medicine, University of Philadelphia, Philadelphia, USA.
2Diagnexia Pty Ltd., Oxford, UK. Runjan.chetty@gmail.com.
3Diagnexia Laboratory, Building B, Langford Locks, Kidlington, Oxford, OX5 1LH, UK. Runjan.chetty@gmail.com.
PubMed DOI

Abstract

Basal crypt dysplasia (BCD) is among the most diagnostically challenging of the non-conventional dysplasia subtypes that arise in the setting of longstanding inflammatory bowel disease (IBD). Its defining characteristic, cytological atypia restricted to the basal compartment of the crypt with a deceptively bland surface epithelium, is contrary to the classical dictum that dysplasia invariably invo…

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