Toward comprehensive cellular characterization of H&E slides.

Benjamin Adjadj¹, Pierre-Antoine Bannier¹, Guillaume Horent¹, Sebastien Mandela¹, Gary Klajer¹, Aurore Lyon¹, Kathryn Schutte¹, Ulysse Marteau¹, Valentin Gaury¹, Laura Dumont¹, Thomas Mathieu¹, Reda Belbahri¹, Benoît Schmauch¹, Eric Durand¹, Katharina Von Loga¹, Lucie Gillet¹

¹Owkin France, Paris, France.

PubMed PMC DOI PDF

Abstract

Cell detection, segmentation, and classification are essential for analyzing tumor microenvironments (TME) on hematoxylin and eosin (H&E) slides. Existing methods suffer from poor performance on understudied cell types (rare or not present in public datasets) and limited cross-domain generalization. To address these shortcomings, we introduce HistoPLUS, a state-of-the-art model for cell analysis,…

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