Immunohistochemical Characterization of Intraocular Inflammation After Intravitreal Administration of Biologics to NHP and Minipigs: A Study Across Compounds.

Theresa C Brömel¹, Barbara Lenz¹, Rachel Neff¹, Typhaine Lejeune², Sylvie Wise², Elke-Astrid Atzpodien¹

¹F. Hoffmann-La Roche Ltd., Basel, Switzerland.

²Charles River Laboratories Montreal ULC, Senneville, QC, Canada.

Abstract

Intraocular inflammation (IOI) following intravitreal (IVT) administration of large molecules (LM) is commonly seen in preclinical species and often relates to the presence of systemic anti-drug antibodies (ADA) as a reaction to the application of human proteins into a non-human species. This retrospective study aimed to characterize histopathological findings of IOI after IVT administration of LM…

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