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Peer-Reviewed Publication
Sci Adv2026;12(34):eaef4377.August 21, 2026Journal Article

High-spatiotemporal resolution deuterium metabolic imaging enables in vivo phenotyping of intra- and intertumoral heterogeneity.

Xinjie Liu1,2, Sufei Wang3, Jinrui Zhao1, ShaSha Wang1, Peng Sun4, Xin Zhou1,2, Maili Liu1,2, Chaoyang Liu1,2, Lucio Frydman5, Qingjia Bao1,2
1State Key Laboratory of Magnetic Resonance Spectroscopy and Imaging, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan 430071, China.
2University of Chinese Academy of Sciences, Beijing 100049, China.
3Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
4Neusoft Medical Systems Co. Ltd., Shenyang 110167, China.
5Weizmann Institute of Science, 7600100 Rehovot, Israel.
PubMed DOI

Abstract

Intra- and intertumoral heterogeneities raise fundamental biological questions and have important implications for accurate cancer diagnosis, prognosis, and treatment. These heterogeneities reflect tumor complexity, including a pronounced diversity in metabolic phenotypes and profiles. This study demonstrates that in vivo deuterium metabolic imaging (DMI) data acquired with sufficiently high spati…

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