AI-Driven Workflow for Automated Colorimetric Isothermal Amplification for Robust Pathogen Detection on Portable Devices.

Ke Xu^1,2,3, Matthew L Cavuto^1,2,3, Kenny Malpartida-Cardenas^1,2, Marcus Pond⁴, Dimbintsoa Rakotomalala Robinson⁵, Francois Kiemde⁶, Bernard Hernandez^1,2,3, Shiranee Sriskandan¹, Umberto D'Alessandro⁵, Annette Erhart⁵, Halidou Tinto⁶, Aubrey J Cunnington¹, Alison Holmes^1,2,7, Pantelis Georgiou³, Nicolas Moser^3,7,8, Jesus Rodriguez-Manzano^1,2,7

¹Department of Infectious Disease, Faculty of Medicine, Imperial College London, London SW7 2AZ, U.K.

²Centre for Antimicrobial Optimisation, Imperial College London, Room 7S5, Commonwealth Building, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, U.K.

³Department of Electrical and Electronic Engineering, Faculty of Engineering, Imperial College London, Exhibition Road, London SW7 2AZ, U.K.

⁴Department of Infection and Immunity, Imperial College Healthcare NHS Trust, St Mary's Hospital, Praed Street, London W2 1NY, U.K.

⁵MRC Unit the Gambia at the London School of Hygiene and Tropical Medicine, Atlantic Boulevard, PO Box 273, Fajara, Banjul 00220, The Gambia.

⁶Unité de Recherche Clinique de Nanoro, Institut de Recherche En Sciences de la Santé, Bp 218 Ouaga 11, Nanoro, Boulkiemdé 10010, Burkina Faso.

⁷The Fleming Initiative, Imperial College London and Imperial College Healthcare NHS Trust, St Mary's Hospital, Praed Street, London W2 1NY, U.K.

⁸Department of Computing, Faculty of Engineering, Imperial College London, London SW7 2AZ, U.K.

PubMed PMC DOI PDF

Abstract

Point-of-Care (POC) portable devices have shown significant potential for rapid pathogen identification in limited-resource settings. Colorimetric LAMP (cLAMP)-based POC nucleic acid testing is particularly promising due to its speed, sensitivity, and simple visual readout. However, there is a need for a universal, automated color detection method to improve ease of use and reduce readout subjecti…

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