Interthalamic adhesion alterations in multiple sclerosis: associations with thalamic damage and cognition.

Arthur Fournet¹, Fanny Munsch², Ismail Koubiyr³, Julie P Vidal⁴, Sergio Morell-Ortega⁵, Aurore Saubusse⁶, Julie Charré-Morin⁶, Katy K Lataste⁶, Audrey Lavielle^1,2, Zhang Bei⁷, Pierrick Coupé⁸, Emmanuel J Barbeau⁹, Vinod J Kumar¹⁰, Michael Hornberger¹¹, Vincent Dousset^1,2,12, Bruno Brochet¹², José V Manjón⁵, Aurélie Ruet^6,12, Thomas Tourdias^13,14,15

¹Neuroimagerie Diagnostique et Thérapeutique, CHU de Bordeaux, 33000, Bordeaux, France.

²Institut de Bio-Imagerie IBIO, Univ. Bordeaux, 33000, Bordeaux, France.

³MS Center Amsterdam, Anatomy and Neurosciences, Amsterdam Neuroscience, Amsterdam UMC Location VUmc, Amsterdam, The Netherlands.

⁴CNRS UMR1214, ToNIC, Université de Toulouse, 31000, Toulouse, France.

⁵Instituto de Aplicaciones de las Tecnologías de la Información y de las Comunicaciones Avanzadas (ITACA), Universitat Politècnica de València, Valencia, Spain.

⁶Service de Neurologie, CRC SEP, CHU de Bordeaux, 33000, Bordeaux, France.

⁷Canon Medical Systems Europe, Amstelveen, The Netherlands.

⁸CNRS, LABRI, UMR5800, PICTURA, Univ. Bordeaux, Bordeaux INP, 33400, Talence, France.

⁹CNRS UMR5549, Centre de Recherche Cerveau et Cognition (Cerco), Université de Toulouse, 31000, Toulouse, France.

¹⁰Max Planck Institute for Biological Cybernetics, Tuebingen, Germany.

¹¹Clinical Neuroscience, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.

¹²INSERM U1215, Neurocentre Magendie, Univ. Bordeaux, 3300, Bordeaux, France.

¹³Neuroimagerie Diagnostique et Thérapeutique, CHU de Bordeaux, 33000, Bordeaux, France. thomas.tourdias@chu-bordeaux.fr.

¹⁴Institut de Bio-Imagerie IBIO, Univ. Bordeaux, 33000, Bordeaux, France. thomas.tourdias@chu-bordeaux.fr.

¹⁵INSERM U1215, Neurocentre Magendie, Univ. Bordeaux, 3300, Bordeaux, France. thomas.tourdias@chu-bordeaux.fr.

PubMed DOI

Abstract

BACKGROUND/OBJECTIVES: We investigated whether the interthalamic adhesion (IA), a midline structure connecting the thalami, is altered in multiple sclerosis (MS) and associated with thalamic damages and cognition. METHODS: We prospectively included 32 clinically isolated syndrome/early MS, 31 relapsing-remitting MS, 31 primary-progressive MS patients, and 103 matched controls. All underwent anato…

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Mentioned Companies

Canon Medical
affiliation

Other Funding

Université de Bordeaux(RRI IMPACT)
Agence Nationale de la Recherche(ANR-23-IAHU-0001)
Agence Nationale de la Recherche(Labex TRAIL)
Ministerio de Ciencia e Innovación(PID2023-152127OB-I00)

MeSH Terms

Humans0Female0Male0Adult0Magnetic Resonance Imaging0Middle Aged0Multiple Sclerosis*Thalamus*Cognitive Dysfunction*Multiple Sclerosis, Chronic Progressive*Prospective Studies0Multiple Sclerosis, Relapsing-Remitting*Demyelinating Diseases*

Keywords

CognitionInterthalamic adhesionMRIMultiple sclerosisNeurodegenerationThalamus

Article Info

PMID: 42624921
DOI: 10.1007/s00415-026-14069-5
Received: April 11, 2026
Accepted: July 12, 2026

How to Cite

Fournet A et al. Interthalamic adhesion alterations in multiple sclerosis: associations with thalamic damage and cognition. J Neurol2026;273(9) doi:10.1007/s00415-026-14069-5

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