Peer-Reviewed Publication
Curr Allergy Asthma Rep2026;26(1)August 20, 2026Journal Article
Central Compartment Atopic Disease Within the Chronic Upper Airway Inflammatory Continuum: A Scoping Review of Sinonasal Compartmentalization and Type-2 Airway Disease.
Ramon Moreno-Luna1,2, Daniel Martin-Jimenez3,4,5, Isam Alobid6,5, Alfonso Del Cuvillo7,5, Serafin Sanchez-Gomez3,5
1Rhinology Unit, Department of Otolaryngology, Head and Neck Surgery, Virgen Macarena University Hospital, Seville, 41009, Spain. ramoluorl@gmail.com.
2Advanced Master's Degree in Rhinology and Anterior Skull Base, Universidad Internacional de Andalucía (UNIA), Dr Fedriani Av. 3, Seville, Spain. ramoluorl@gmail.com.
3Rhinology Unit, Department of Otolaryngology, Head and Neck Surgery, Virgen Macarena University Hospital, Seville, 41009, Spain.
4Department of Otorhinolaryngology, University Hospital of La Ribera, Valencia, 46600, Spain.
5Advanced Master's Degree in Rhinology and Anterior Skull Base, Universidad Internacional de Andalucía (UNIA), Dr Fedriani Av. 3, Seville, Spain.
6Rhinology and Skull Base Unit, Department of Otorhinolaryngology, Hospital Clinic, Universitat de Barcelona, IDIBAPS, CIBERES, Barcelona, 08036, Spain.
7Rhinology & Asthma Unit. ENT Department, Hospital Universitario de Jerez, Cadiz, 11407, Spain.
Abstract
PURPOSE OF REVIEW: To map evidence supporting a chronic upper airway inflammatory continuum (CUAIC) linking localized allergic inflammation, central compartment atopic disease (CCAD), diffuse type 2 chronic rhinosinusitis (CRS), and broader T2-airway disease.
RECENT FINDINGS: A scoping review of five databases identified 58 studies from January 2014 to April 2026. Evidence described a non-linear…
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